atg-7 Ubiquitin-like modifier-activating enzyme ATG7 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: atg-7
Official Full Name: Ubiquitin-like modifier-activating enzyme ATG7
Primary source: WormBase:WBGene00010882
Locus tag: CELE_M7.5
See related: AllianceGenome:WB:WBGene00010882
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable Atg12 activating enzyme activity and Atg8 activating enzyme activity. Involved in several processes, including dauer larval development; determination of adult lifespan; and positive regulation of autophagosome assembly. Predicted to be active in phagophore assembly site. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 31. Orthologous to human ATG7 (autophagy related 7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See atg-7 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (11078682..11081055, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M7.5 (e-PCR)
- UniSTS:312697

M7.1 (e-PCR)
- UniSTS:316911

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables Atg12 activating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables Atg8 activating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like modifier activating enzyme activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in autophagy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to nitrogen starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of autophagosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein modification by small protein conjugation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
located_in phagophore assembly site	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ubiquitin-like modifier-activating enzyme ATG7

NP_502064.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

11078682..11081055 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069663.6 → NP_502064.1 Ubiquitin-like modifier-activating enzyme ATG7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502064.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EBK4

Conserved Domains (1) summary

TIGR01381
Location:4 → 635

E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p