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gtl-1 TRPM SLOG domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 178031, updated on 2-Nov-2024

Summary

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Official Symbol
gtl-1
Official Full Name
TRPM SLOG domain-containing protein
Primary source
WormBase:WBGene00001795
Locus tag
CELE_C05C12.3
See related
AllianceGenome:WB:WBGene00001795
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable monoatomic cation channel activity. Involved in defecation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in intestine; nervous system; and rectal gland cell. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1; cataract; congenital stationary night blindness; and congenital stationary night blindness 1C. Orthologous to human TRPM1 (transient receptor potential cation channel subfamily M member 1); TRPM3 (transient receptor potential cation channel subfamily M member 3); and TRPM7 (transient receptor potential cation channel subfamily M member 7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gtl-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
32
Sequence:
Chromosome: IV; NC_003282.8 (11248884..11259535, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene EGF-like domain-containing protein Neighboring gene Protein kinase domain-containing protein Neighboring gene Phosphoprotein Neighboring gene KH domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GTL-1, a Calcium Activated TRPM Channel, Enhances Nociception. Cohen E, et al. Front Pharmacol, 2019. PMID 32009965, Free PMC Article
  2. TRPM channel function in Caenorhabditis elegans. Baylis HA, et al. Biochem Soc Trans, 2007 Feb. PMID 17233618
  3. Highly Ca2+-selective TRPM channels regulate IP3-dependent oscillatory Ca2+ signaling in the C. elegans intestine. Xing J, et al. J Gen Physiol, 2008 Mar. PMID 18299395, Free PMC Article
  4. Optogenetic analysis of a nociceptor neuron and network reveals ion channels acting downstream of primary sensors. Husson SJ, et al. Curr Biol, 2012 May 8. PMID 22483941, Free PMC Article
  5. Differential regulation of TRPM channels governs electrolyte homeostasis in the C. elegans intestine. Teramoto T, et al. Cell Metab, 2005 May. PMID 16054081, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the activity of GTL-2 balances the activities of the paralogous TRPM channel proteins, GON-2 and GTL-1
    Title: Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel.
  2. PIP(2)-dependent regulation of GON-2/GTL-1 may provide a mechanism to coordinate plasma membrane Ca(2+) influx with PLCgamma and IP(3) receptor activity as well as intracellular Ca(2+) store depletion.
    Title: Phosphatidylinositol 4,5-bisphosphate and loss of PLCgamma activity inhibit TRPM channels required for oscillatory Ca2+ signaling.
  3. The GTL-1 mainly contributes to appropriate Mg(2+) responsiveness of the outwardly rectifying current.
    Title: Differential regulation of TRPM channels governs electrolyte homeostasis in the C. elegans intestine.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables monoatomic cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in defecation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in defecation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in metal ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic cation transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TRPM SLOG domain-containing protein
NP_502111.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11248884..11259535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069710.6 → NP_502111.3  TRPM SLOG domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502111.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECM4, Q8IG05
    Conserved Domains (2) summary
    pfam00520
    Location:1081 → 1328
    Ion_trans; Ion transport protein
    pfam18139
    Location:208 → 471
    LSDAT_euk; SLOG in TRPM
Nucleotide Protein
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