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gspd-1 Glucose-6-phosphate 1-dehydrogenase [ Caenorhabditis elegans ]

Gene ID: 178046, updated on 2-Nov-2024

Summary

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Official Symbol
gspd-1
Official Full Name
Glucose-6-phosphate 1-dehydrogenase
Primary source
WormBase:WBGene00007108
Locus tag
CELE_B0035.5
See related
AllianceGenome:WB:WBGene00007108
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glucose-6-phosphate dehydrogenase activity. Predicted to be involved in glucose metabolic process and pentose-phosphate shunt, oxidative branch. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in intestine; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cerebrovascular disease; favism; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gspd-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
9
Sequence:
Chromosome: IV; NC_003282.8 (11317419..11319951)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene putative prefoldin subunit 4 Neighboring gene Mitochondrial cytochrome c oxidase subunit VIc/VIIs domain-containing protein Neighboring gene Protein edg-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Modeling human glucose-6-phosphate dehydrogenase mutations using C. elegans GSPD-1. Loges LN, et al. MicroPubl Biol, 2021. PMID 34532700, Free PMC Article
  2. tert-Butyl Hydroperoxide (tBHP)-Induced Lipid Peroxidation and Embryonic Defects Resemble Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency in C. elegans. Yang HC, et al. Int J Mol Sci, 2020 Nov 18. PMID 33217954, Free PMC Article
  3. The impact of glucose on mitochondria and life span is determined by the integrity of proline catabolism in Caenorhabditis elegans. Feng X, et al. J Biol Chem, 2023 Feb. PMID 36626986, Free PMC Article
  4. Impaired embryonic development in glucose-6-phosphate dehydrogenase-deficient Caenorhabditis elegans due to abnormal redox homeostasis induced activation of calcium-independent phospholipase and alteration of glycerophospholipid metabolism. Chen TL, et al. Cell Death Dis, 2017 Jan 12. PMID 28079896, Free PMC Article
  5. Glucose-6-phosphate dehydrogenase modulates vascular endothelial growth factor-mediated angiogenesis. Leopold JA, et al. J Biol Chem, 2003 Aug 22. PMID 12777375

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. tert-Butyl Hydroperoxide (tBHP)-Induced Lipid Peroxidation and Embryonic Defects Resemble Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency in C. elegans.
    Title: tert-Butyl Hydroperoxide (tBHP)-Induced Lipid Peroxidation and Embryonic Defects Resemble Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency in C. elegans.
  2. Abnormal glycerophospholipid metabolism leading to defective embryonic development could be attributed to the increased activity of calcium-independent phospholipase A2 (iPLA) in G6PD-deficient embryos. This notion is further supported by the fact that the suppression of multiple iPLAs by genetic manipulation partially rescued the embryonic defects in G6PD-deficient embryos.
    Title: Impaired embryonic development in glucose-6-phosphate dehydrogenase-deficient Caenorhabditis elegans due to abnormal redox homeostasis induced activation of calcium-independent phospholipase and alteration of glycerophospholipid metabolism.
  3. role in modulating vascular endothelial growth factor-mediated angiogenesis
    Title: Glucose-6-phosphate dehydrogenase modulates vascular endothelial growth factor-mediated angiogenesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables glucose-6-phosphate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucose-6-phosphate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucose-6-phosphate dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on CH-OH group of donors IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NADP metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glucose 6-phosphate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose-phosphate shunt IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose-phosphate shunt, oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Glucose-6-phosphate 1-dehydrogenase
NP_502129.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11317419..11319951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069728.7 → NP_502129.1  Glucose-6-phosphate 1-dehydrogenase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502129.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q27464
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q27464.1

Gene LinkOut

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