catp-8 putative manganese-transporting ATPase catp-8 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: catp-8
Official Full Name: putative manganese-transporting ATPase catp-8
Primary source: WormBase:WBGene00007514
Locus tag: CELE_C10C6.6
See related: AllianceGenome:WB:WBGene00007514
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATPase-coupled monoatomic cation transmembrane transporter activity; P-type ion transporter activity; and protein transporter activity. Acts upstream of with a positive effect on dendrite morphogenesis. Located in endoplasmic reticulum. Is expressed in several structures, including body wall musculature; gonad; intestine; neurons; and pharynx. Orthologous to human ATP13A1 (ATPase 13A1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See catp-8 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 9

Sequence:: Chromosome: IV; NC_003282.8 (11473363..11479251, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

P5A ATPase controls ER translocation of Wnt in neuronal migration.
Title: P5A ATPase controls ER translocation of Wnt in neuronal migration.
The CATP-8/P5A-type ATPase functions in multiple pathways during neuronal patterning.
Title: The CATP-8/P5A-type ATPase functions in multiple pathways during neuronal patterning.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C10C6.6 (e-PCR)
- UniSTS:307243

H21P03.1 (e-PCR)
- UniSTS:320575

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled monoatomic cation transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables P-type ion transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables P-type transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_positive_effect dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative manganese-transporting ATPase catp-8

NP_502165.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

11473363..11479251 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069764.6 → NP_502165.2 putative manganese-transporting ATPase catp-8 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502165.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O02620, P90747

Conserved Domains (4) summary

COG4087
Location:793 → 842

COG4087; Soluble P-type ATPase [General function prediction only]

TIGR01657
Location:37 → 1153

P-ATPase-V; P-type ATPase of unknown pump specificity (type V)

pfam00122
Location:251 → 380

E1-E2_ATPase; E1-E2 ATPase

pfam13246
Location:532 → 613

Cation_ATPase; Cation transport ATPase (P-type)