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sms-1 Phosphatidylcholine:ceramide cholinephosphotransferase 1 [ Caenorhabditis elegans ]

Gene ID: 178072, updated on 2-Nov-2024

Summary

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Official Symbol
sms-1
Official Full Name
Phosphatidylcholine:ceramide cholinephosphotransferase 1
Primary source
WormBase:WBGene00004892
Locus tag
CELE_H21P03.3
See related
AllianceGenome:WB:WBGene00004892
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ceramide cholinephosphotransferase activity and sphingomyelin synthase activity. Predicted to be involved in ceramide biosynthetic process and sphingomyelin biosynthetic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in Golgi membrane; endoplasmic reticulum membrane; and plasma membrane. Is expressed in several structures, including body wall musculature; pharyngeal cell; rectal muscle; ventral nerve cord; and vulval muscle. Human ortholog(s) of this gene implicated in calvarial doughnut lesions with bone fragility. Orthologous to several human genes including SGMS2 (sphingomyelin synthase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sms-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (11482662..11498174, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene HTH cro/C1-type domain-containing protein Neighboring gene Non-structural maintenance of chromosomes element 4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene BPTI/Kunitz inhibitor domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Clozapine Modulates Glucosylceramide, Clears Aggregated Proteins, and Enhances ATG8/LC3 in Caenorhabditis elegans. Hao L, et al. Neuropsychopharmacology, 2017 Mar. PMID 27711049, Free PMC Article
  2. Caenorhabditis elegans Heterochromatin protein 1 (HPL-2) links developmental plasticity, longevity and lipid metabolism. Meister P, et al. Genome Biol, 2011 Dec 20. PMID 22185090, Free PMC Article
  3. Sphingolipid profiling reveals differential functions of sphingolipid biosynthesis isozymes of Caenorhabditis elegans. Luo H, et al. J Lipid Res, 2024 Jun. PMID 38704027, Free PMC Article
  4. Identification of a family of animal sphingomyelin synthases. Huitema K, et al. EMBO J, 2004 Jan 14. PMID 14685263, Free PMC Article
  5. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ceramide cholinephosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ceramide cholinephosphotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables phosphotransferase activity, for other substituted phosphate groups IEA
Inferred from Electronic Annotation
more info
  
enables sphingomyelin synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sphingomyelin synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingomyelin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingomyelin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Phosphatidylcholine:ceramide cholinephosphotransferase 1
NP_001129861.2
  • Partially confirmed by transcript evidence
NP_001255559.1
  • Partially confirmed by transcript evidence
NP_502168.2
  • Partially confirmed by transcript evidence
NP_502169.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11482662..11498174 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069767.6 → NP_502168.2  Phosphatidylcholine:ceramide cholinephosphotransferase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502168.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B3GWD9, H2L2K5, Q9U3D4, Q9XTV2
    Conserved Domains (2) summary
    pfam03247
    Location:17 → 121
    Prothymosin; Prothymosin/parathymosin family
    pfam14360
    Location:327 → 400
    PAP2_C; PAP2 superfamily C-terminal

  2. NM_069768.6 → NP_502169.2  Phosphatidylcholine:ceramide cholinephosphotransferase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502169.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U3D4
    Conserved Domains (2) summary
    pfam03247
    Location:6 → 81
    Prothymosin; Prothymosin/parathymosin family
    pfam14360
    Location:287 → 360
    PAP2_C; PAP2 superfamily C-terminal

  3. NM_001268630.3 → NP_001255559.1  Phosphatidylcholine:ceramide cholinephosphotransferase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255559.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L2K5
    Conserved Domains (2) summary
    pfam05793
    Location:1 → 128
    TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
    pfam14360
    Location:273 → 346
    PAP2_C; PAP2 superfamily C-terminal

  4. NM_001136389.4 → NP_001129861.2  Phosphatidylcholine:ceramide cholinephosphotransferase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129861.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U3D4
    Conserved Domains (1) summary
    pfam14360
    Location:210 → 283
    PAP2_C; PAP2 superfamily C-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U3D4.2

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