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sec-24.1 Protein transport protein Sec24C [ Caenorhabditis elegans ]

Gene ID: 178078, updated on 2-Nov-2024

Summary

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Official Symbol
sec-24.1
Official Full Name
Protein transport protein Sec24C
Primary source
WormBase:WBGene00004755
Locus tag
CELE_F12F6.6
See related
AllianceGenome:WB:WBGene00004755
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable SNARE binding activity and zinc ion binding activity. Predicted to be involved in COPII-coated vesicle cargo loading. Predicted to be located in ER to Golgi transport vesicle membrane and endoplasmic reticulum membrane. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Is expressed in several structures, including intestine. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Orthologous to several human genes including SEC24D (SEC24 homolog D, COPII coat complex component). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sec-24.1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
9
Sequence:
Chromosome: IV; NC_003282.8 (11561986..11566194, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene putative DNA polymerase delta small subunit Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sar1 GTPase Activity Is Regulated by Membrane Curvature. Hanna MG 4th, et al. J Biol Chem, 2016 Jan 15. PMID 26546679, Free PMC Article
  2. Caenorhabditis elegans paraoxonase-like proteins control the functional expression of DEG/ENaC mechanosensory proteins. Chen Y, et al. Mol Biol Cell, 2016 Apr 15. PMID 26941331, Free PMC Article
  3. GATA transcription factor required for immunity to bacterial and fungal pathogens. Kerry S, et al. PLoS One, 2006 Dec 20. PMID 17183709, Free PMC Article
  4. ERGIC2 and ERGIC3 regulate the ER-to-Golgi transport of gap junction proteins in metazoans. Guan L, et al. Traffic, 2022 Mar. PMID 34994051
  5. SMGL-1/NBAS acts as a RAB-8 GEF to regulate unconventional protein secretion. Wang X, et al. J Cell Biol, 2022 Jul 4. PMID 35604368, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in COPII-coated vesicle cargo loading IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of COPII vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COPII vesicle coat IEA
Inferred from Electronic Annotation
more info
  
located_in ER to Golgi transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein transport protein Sec24C
NP_502178.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11561986..11566194 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069777.4 → NP_502178.1  Protein transport protein Sec24C [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502178.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19371
    Conserved Domains (6) summary
    cd01479
    Location:531 → 777
    Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
    pfam00626
    Location:996 → 1069
    Gelsolin; Gelsolin repeat
    pfam04810
    Location:454 → 488
    zf-Sec23_Sec24; Sec23/Sec24 zinc finger
    pfam04815
    Location:876 → 971
    Sec23_helical; Sec23/Sec24 helical domain
    pfam08033
    Location:778 → 861
    Sec23_BS; Sec23/Sec24 beta-sandwich domain
    pfam15822
    Location:47 → 267
    MISS; MAPK-interacting and spindle-stabilizing protein-like
Nucleotide Protein
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