U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ragc-1 Ras-related GTP-binding protein C [ Caenorhabditis elegans ]

Gene ID: 178084, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
ragc-1
Official Full Name
Ras-related GTP-binding protein C
Primary source
WormBase:WBGene00012497
Locus tag
CELE_Y24F12A.2
See related
AllianceGenome:WB:WBGene00012497
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTP binding activity and GTPase activity. Involved in determination of adult lifespan and regulation of autophagosome assembly. Predicted to be located in membrane. Predicted to be part of Gtr1-Gtr2 GTPase complex. Predicted to be active in lysosome and nucleus. Is expressed in intestine. Human ortholog(s) of this gene implicated in renal hypomagnesemia 7, with or without dilated cardiomyopathy. Orthologous to human RRAGC (Ras related GTP binding C) and RRAGD (Ras related GTP binding D). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ragc-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (11603613..11604933, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Abnormal cell migration protein 38 Neighboring gene Small ribosomal subunit protein uS17 Neighboring gene Deoxyribonuclease TATDN2 Neighboring gene pseudo

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival. Murphy JT, et al. PLoS Biol, 2019 May. PMID 31086360, Free PMC Article
  2. Nutritional control of postembryonic development progression and arrest in Caenorhabditis elegans. Mata-Cabana A, et al. Adv Genet, 2021. PMID 33641748
  3. mTOR Regulates Phase Separation of PGL Granules to Modulate Their Autophagic Degradation. Zhang G, et al. Cell, 2018 Sep 6. PMID 30173914
  4. TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Robida-Stubbs S, et al. Cell Metab, 2012 May 2. PMID 22560223, Free PMC Article
  5. Surviving starvation simply without TFEB. Soukas AA, et al. PLoS Biol, 2019 May. PMID 31136567, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Gtr1-Gtr2 GTPase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Ras-related GTP-binding protein C
NP_001293887.1
  • Confirmed by transcript evidence
NP_502187.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11603613..11604933 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069786.6 → NP_502187.1  Ras-related GTP-binding protein C [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502187.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EGB3
    Conserved Domains (1) summary
    cd11385
    Location:28 → 201
    RagC_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D

  2. NM_001306958.3 → NP_001293887.1  Ras-related GTP-binding protein C [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293887.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061ACG4
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.