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acl-3 Tafazzin family protein [ Caenorhabditis elegans ]

Gene ID: 178095, updated on 2-Nov-2024

Summary

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Official Symbol
acl-3
Official Full Name
Tafazzin family protein
Primary source
WormBase:WBGene00006491
Locus tag
CELE_ZK809.2
See related
AllianceGenome:WB:WBGene00006491
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 1-acylglycerophosphocholine O-acyltransferase activity. Predicted to be involved in cardiolipin acyl-chain remodeling and inner mitochondrial membrane organization. Predicted to be located in mitochondrial inner membrane and mitochondrial outer membrane. Predicted to be active in mitochondrial membrane. Human ortholog(s) of this gene implicated in Barth syndrome and dilated cardiomyopathy. Orthologous to human TAFAZZIN (tafazzin, phospholipid-lysophospholipid transacylase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See acl-3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (11650715..11652023, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene RING-type domain-containing protein Neighboring gene Cardiac phospholamban Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 Neighboring gene Equilibrative nucleoside transporter 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inactivation of cardiolipin synthase triggers changes in mitochondrial morphology. Matsumura A, et al. FEBS Lett, 2018 Jan. PMID 29251771
  2. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 1-acylglycerophosphocholine O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cardiolipin acyl-chain remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inner mitochondrial membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tafazzin family protein
NP_502202.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11650715..11652023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069801.5 → NP_502202.2  Tafazzin family protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502202.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q23598
    Conserved Domains (1) summary
    pfam01553
    Location:54 → 198
    Acyltransferase; Acyltransferase
Nucleotide Protein
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