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nhr-43 Nuclear hormone receptor family member nhr-43 [ Caenorhabditis elegans ]

Gene ID: 178121, updated on 2-Nov-2024

Summary

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Official Symbol
nhr-43
Official Full Name
Nuclear hormone receptor family member nhr-43
Primary source
WormBase:WBGene00003633
Locus tag
CELE_C29E6.5
See related
AllianceGenome:WB:WBGene00003633
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in dorsal nerve cord; excretory cell; head neurons; hypodermis; and intestine. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nhr-43 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (11899590..11902976)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Protein let-653 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene Delta(9)-fatty-acid desaturase fat-6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple transcription factors directly regulate Hox gene lin-39 expression in ventral hypodermal cells of the C. elegans embryo and larva, including the hypodermal fate regulators LIN-26 and ELT-6. Liu WJ, et al. BMC Dev Biol, 2014 May 13. PMID 24885717, Free PMC Article
  2. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
  3. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nuclear hormone receptor family member nhr-43
NP_001293976.1
  • Confirmed by transcript evidence
NP_502254.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11899590..11902976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001307047.3 → NP_001293976.1  Nuclear hormone receptor family member nhr-43 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293976.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061AJB0
    Conserved Domains (2) summary
    smart00399
    Location:47 → 117
    ZnF_C4; c4 zinc finger in nuclear hormone receptors
    pfam00104
    Location:230 → 427
    Hormone_recep; Ligand-binding domain of nuclear hormone receptor

  2. NM_069853.6 → NP_502254.1  Nuclear hormone receptor family member nhr-43 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502254.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A061AJB0, Q18299, Q9GTH4
    Conserved Domains (2) summary
    smart00399
    Location:47 → 118
    ZnF_C4; c4 zinc finger in nuclear hormone receptors
    pfam00104
    Location:231 → 428
    Hormone_recep; Ligand-binding domain of nuclear hormone receptor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q18299.1

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