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wdr-46 WD repeat-containing protein 46 [ Caenorhabditis elegans ]

Gene ID: 178185, updated on 2-Nov-2024

Summary

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Official Symbol
wdr-46
Official Full Name
WD repeat-containing protein 46
Primary source
WormBase:WBGene00009211
Locus tag
CELE_F28D1.1
See related
AllianceGenome:WB:WBGene00009211
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Is expressed in body wall musculature; germ line; head; hypodermis; and intestine. Orthologous to human WDR46 (WD repeat domain 46). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See wdr-46 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (12372253..12374834)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Glutathione S-transferase Neighboring gene poly(A)-specific ribonuclease Neighboring gene ncRNA Neighboring gene Protein atz-1 Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Pathogenesis-related protein 5-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Depletion of a nucleolar protein activates xenobiotic detoxification genes in Caenorhabditis elegans via Nrf /SKN-1 and p53/CEP-1. Leung CK, et al. Free Radic Biol Med, 2012 Mar 1. PMID 22240150
  2. The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans. Choe KP, et al. Mol Cell Biol, 2009 May. PMID 19273594, Free PMC Article
  3. Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. Tan D, et al. Elife, 2016 Mar 8. PMID 26952210, Free PMC Article
  4. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
  5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WDR-46 is expressed in the nucleoli of multiple tissues in C. elegans and is required for rRNA processing.
    Title: Depletion of a nucleolar protein activates xenobiotic detoxification genes in Caenorhabditis elegans via Nrf /SKN-1 and p53/CEP-1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
WD repeat-containing protein 46
NP_502358.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    12372253..12374834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069957.8 → NP_502358.1  WD repeat-containing protein 46 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502358.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19873
    Conserved Domains (3) summary
    smart01033
    Location:409 → 487
    BING4CT; BING4CT (NUC141) domain
    sd00039
    Location:213 → 250
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:161 → 426
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
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Gene LinkOut

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