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gex-3 Membrane-associated protein gex-3 [ Caenorhabditis elegans ]

Gene ID: 178191, updated on 2-Nov-2024

Summary

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Official Symbol
gex-3
Official Full Name
Membrane-associated protein gex-3
Primary source
WormBase:WBGene00001580
Locus tag
CELE_F28D1.10
See related
AllianceGenome:WB:WBGene00001580
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in several processes, including egg-laying behavior; embryonic morphogenesis; and positive regulation of cellular component organization. Located in cell junction. Part of SCAR complex. Is expressed in intestinal cell. Human ortholog(s) of this gene implicated in immunodeficiency 72. Orthologous to several human genes including NCKAP1 (NCK associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gex-3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
12
Sequence:
Chromosome: IV; NC_003282.8 (12404431..12408690)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Double-Strand Break factor Neighboring gene Acyltransferase C-terminal domain-containing protein;Phospholipid/glycerol acyltransferase domain-containing protein Neighboring gene BMERB domain-containing protein;Mnd1 domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A mutation in F-actin polymerization factor suppresses the distal arthrogryposis type 5 PIEZO2 pathogenic variant in Caenorhabditis elegans. Bai X, et al. Development, 2024 Feb 15. PMID 38349741, Free PMC Article
  2. Robo functions as an attractive cue for glial migration through SYG-1/Neph. Qu Z, et al. Elife, 2020 Nov 19. PMID 33211005, Free PMC Article
  3. NLR-1/CASPR Anchors F-Actin to Promote Gap Junction Formation. Meng L, et al. Dev Cell, 2020 Dec 7. PMID 33238150, Free PMC Article
  4. The branched actin nucleator Arp2/3 promotes nuclear migrations and cell polarity in the C. elegans zygote. Xiong H, et al. Dev Biol, 2011 Sep 15. PMID 21798253, Free PMC Article
  5. The WAVE/SCAR complex promotes polarized cell movements and actin enrichment in epithelia during C. elegans embryogenesis. Patel FB, et al. Dev Biol, 2008 Dec 15. PMID 18938151, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A mutation in F-actin polymerization factor suppresses the distal arthrogryposis type 5 PIEZO2 pathogenic variant in Caenorhabditis elegans.
    Title: A mutation in F-actin polymerization factor suppresses the distal arthrogryposis type 5 PIEZO2 pathogenic variant in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in collateral sprouting IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cortical actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic ectodermal digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of clathrin-dependent endocytosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of clathrin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of egg-laying behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gap junction assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SCAR complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCAR complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Membrane-associated protein gex-3
NP_502368.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    12404431..12408690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069967.7 → NP_502368.1  Membrane-associated protein gex-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502368.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P55163, Q19880
    Conserved Domains (1) summary
    pfam09735
    Location:11 → 1138
    Nckap1; Membrane-associated apoptosis protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P55163.2

Gene LinkOut

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