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ham-1 Stork-head box protein ham-1 [ Caenorhabditis elegans ]

Gene ID: 178205, updated on 2-Nov-2024

Summary

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Official Symbol
ham-1
Official Full Name
Stork-head box protein ham-1
Primary source
WormBase:WBGene00001820
Locus tag
CELE_F53B2.6
See related
AllianceGenome:WB:WBGene00001820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including asymmetric protein localization involved in cell fate determination; generation of neurons; and protein localization to actomyosin contractile ring. Located in cell cortex and nucleus. Is expressed in several structures, including anal region; digestive tract; gonad; head; and midbody. Human ortholog(s) of this gene implicated in pre-eclampsia. Orthologous to several human genes including STOX1 (storkhead box 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ham-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (12542183..12545737)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Kinase Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans gene ham-1 regulates daughter cell size asymmetry primarily in divisions that produce a small anterior daughter cell. Teuliere J, et al. PLoS One, 2018. PMID 29668718, Free PMC Article
  2. C. elegans HAM-1 functions in the nucleus to regulate asymmetric neuroblast division. Leung A, et al. Dev Biol, 2016 Feb 1. PMID 26703426
  3. A proneural gene controls C. elegans neuroblast asymmetric division and migration. Zhu Z, et al. FEBS Lett, 2014 Apr 2. PMID 24589937
  4. C. elegans HAM-1 positions the cleavage plane and regulates apoptosis in asymmetric neuroblast divisions. Frank CA, et al. Dev Biol, 2005 Aug 15. PMID 15979607
  5. Comparative genetic, proteomic and phosphoproteomic analysis of C. elegans embryos with a focus on ham-1/STOX and pig-1/MELK in dopaminergic neuron development. Offenburger SL, et al. Sci Rep, 2017 Jun 28. PMID 28659600, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. While ham-1 function is essential for asymmetric division in the lineage that generates the PLM mechanosensory neuron, we showed that cortical localization may not required
    Title: C. elegans HAM-1 functions in the nucleus to regulate asymmetric neuroblast division.
  2. TBX-2, along with HAM-1, regulates the migrations of the HSN motor neurons and prevents the PHB sensory neurons from adopting an apoptotic fate.
    Title: The T-box gene tbx-2, the homeobox gene egl-5 and the asymmetric cell division gene ham-1 specify neural fate in the HSN/PHB lineage.
  3. Ham-1 positions the cleavage plane and regulates apoptosis in asymmetric neuroblast divisions.
    Title: C. elegans HAM-1 positions the cleavage plane and regulates apoptosis in asymmetric neuroblast divisions.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in asymmetric neuroblast division IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in asymmetric neuroblast division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in asymmetric protein localization involved in cell fate determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell fate determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dopaminergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to actomyosin contractile ring IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in spindle localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Stork-head box protein ham-1
NP_502401.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    12542183..12545737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070000.8 → NP_502401.1  Stork-head box protein ham-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502401.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EEC5
    Conserved Domains (1) summary
    pfam10264
    Location:93 → 169
    Stork_head; Winged helix Storkhead-box1 domain
Nucleotide Protein
Heading Accession and Version

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