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efa-6 Exchange factor for Arf-6 [ Caenorhabditis elegans ]

Gene ID: 178217, updated on 2-Nov-2024

Summary

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Official Symbol
efa-6
Official Full Name
Exchange factor for Arf-6
Primary source
WormBase:WBGene00013223
Locus tag
CELE_Y55D9A.1
See related
AllianceGenome:WB:WBGene00013223
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in several processes, including mitotic nuclear membrane disassembly; negative regulation of axon extension involved in regeneration; and regulation of cell cycle process. Located in cell cortex; microtubule minus-end; and plasma membrane. Is expressed in U.la; U.lp; and linker cell. Orthologous to several human genes including PSD (pleckstrin and Sec7 domain containing). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See efa-6 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
10
Sequence:
Chromosome: IV; NC_003282.8 (12605695..12614724, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Multidrug resistance protein pgp-1 Neighboring gene ncRNA Neighboring gene tRNA-Lys Neighboring gene G-patch domain-containing protein Neighboring gene Ack-related non-receptor tyrosine kinase Neighboring gene Transcriptional regulator

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The microtubule regulator EFA-6 forms cortical foci dependent on its intrinsically disordered region and interactions with tubulins. Sandhu A, et al. Cell Rep, 2024 Oct 22. PMID 39305484
  2. Regulation of Microtubule Dynamics in Axon Regeneration: Insights from C. elegans. Tang NH, et al. F1000Res, 2016. PMID 27350865, Free PMC Article
  3. Recent advances in the understanding and management of IgA nephropathy. Lai KN, et al. F1000Res, 2016. PMID 26918170, Free PMC Article
  4. Axon regeneration pathways identified by systematic genetic screening in C. elegans. Chen L, et al. Neuron, 2011 Sep 22. PMID 21943602, Free PMC Article
  5. DIP-2 suppresses ectopic neurite sprouting and axonal regeneration in mature neurons. Noblett N, et al. J Cell Biol, 2019 Jan 7. PMID 30396999, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The microtubule regulator EFA-6 forms cortical foci dependent on its intrinsically disordered region and interactions with tubulins.
    Title: The microtubule regulator EFA-6 forms cortical foci dependent on its intrinsically disordered region and interactions with tubulins.
  2. It loss of EFA-6, a modulator of MT dynamics, can delay both neuronal aging and extend the lifespan of C. elegans.
    Title: Microtubule regulators act in the nervous system to modulate fat metabolism and longevity through DAF-16 in C. elegans.
  3. The EFA-6 N-terminus binds the microtubule-associated proteins TAC-1/Transforming-Acidic-Coiled-Coil, and ZYG-8/Doublecortin-Like-Kinase, both of which are required for regenerative growth cone formation, and which act downstream of EFA-6.
    Title: Axon injury triggers EFA-6 mediated destabilization of axonal microtubules via TACC and doublecortin like kinase.
  4. C. elegans EFA-6 amino-terminus is both necessary and sufficient to limit microtubule growth along the cortex, and that this function is independent of ARF-6.
    Title: Caenorhabditis elegans EFA-6 limits microtubule growth at the cell cortex.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic nuclear membrane disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of axon extension involved in regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of axon regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of mitotic spindle elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of microtubule cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mitotic centrosome separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to axon injury IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule minus-end IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Exchange factor for Arf-6
NP_001122818.1
  • Confirmed by transcript evidence
NP_001255652.1
  • Confirmed by transcript evidence
NP_502416.1
  • Confirmed by transcript evidence
NP_502417.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    12605695..12614724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070015.7 → NP_502416.1  Exchange factor for Arf-6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502416.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D4YWC5, G5EBY7, G5EET6, Q9XWG7
    Conserved Domains (3) summary
    smart00222
    Location:350 → 534
    Sec7; Sec7 domain
    cd13295
    Location:565 → 689
    PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
    pfam00169
    Location:571 → 681
    PH; PH domain

  2. NM_001129346.3 → NP_001122818.1  Exchange factor for Arf-6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122818.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EET6
    Conserved Domains (4) summary
    smart00222
    Location:297 → 481
    Sec7; Sec7 domain
    cd13295
    Location:512 → 636
    PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
    pfam00169
    Location:518 → 628
    PH; PH domain
    cl01319
    Location:139 → 192
    HARE-HTH; HB1, ASXL, restriction endonuclease HTH domain

  3. NM_070016.7 → NP_502417.1  Exchange factor for Arf-6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502417.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EET6
    Conserved Domains (3) summary
    smart00222
    Location:348 → 532
    Sec7; Sec7 domain
    cd13295
    Location:563 → 687
    PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
    pfam00169
    Location:569 → 679
    PH; PH domain

  4. NM_001268723.3 → NP_001255652.1  Exchange factor for Arf-6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255652.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EET6
    Conserved Domains (3) summary
    smart00222
    Location:166 → 350
    Sec7; Sec7 domain
    cd13295
    Location:381 → 505
    PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
    pfam00169
    Location:387 → 497
    PH; PH domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EET6.1

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