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inx-6 Innexin-6 [ Caenorhabditis elegans ]

Gene ID: 178231, updated on 2-Nov-2024

Summary

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Official Symbol
inx-6
Official Full Name
Innexin-6
Primary source
WormBase:WBGene00002128
Locus tag
CELE_C36H8.2
See related
AllianceGenome:WB:WBGene00002128
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable gap junction hemi-channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be active in gap junction and plasma membrane. Is expressed in head neurons; pharynx; and rectal valve cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See inx-6 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (12746584..12749721)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene MAM domain-containing protein Neighboring gene ncRNA Neighboring gene Major sperm protein Neighboring gene KPSFVRF-amide 2 Neighboring gene SHSP domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids. Burendei B, et al. Sci Adv, 2020 Feb. PMID 32095518, Free PMC Article
  2. Atomic structure of the innexin-6 gap junction channel determined by cryo-EM. Oshima A, et al. Nat Commun, 2016 Dec 1. PMID 27905396, Free PMC Article
  3. Oligomeric structure and functional characterization of Caenorhabditis elegans Innexin-6 gap junction protein. Oshima A, et al. J Biol Chem, 2013 Apr 12. PMID 23460640, Free PMC Article
  4. Hexadecameric structure of an invertebrate gap junction channel. Oshima A, et al. J Mol Biol, 2016 Mar 27. PMID 26883891
  5. Regulation of intermuscular electrical coupling by the Caenorhabditis elegans innexin inx-6. Li S, et al. Mol Biol Cell, 2003 Jul. PMID 12857852, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids.
    Title: Cryo-EM structures of undocked innexin-6 hemichannels in phospholipids.
  2. the INX-6 cytoplasmic domains are cooperatively associated with the N-terminal funnel conformation, and an essential linkage of the N-terminal with channel activity is presumably preserved across gap junction families.
    Title: Atomic structure of the innexin-6 gap junction channel determined by cryo-EM.
  3. The three-dimensional reconstruction determined by cryo-electron crystallography reveals that a single INX-6 gap junction channel comprises 16 subunits, a hexadecamer, in contrast to chordate connexin channels, which comprise 12 subunits.
    Title: Hexadecameric structure of an invertebrate gap junction channel.
  4. INX-6 channels have a larger overall structure and greater permeability than connexin channels.
    Title: Oligomeric structure and functional characterization of Caenorhabditis elegans Innexin-6 gap junction protein.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables gap junction channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables gap junction channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables gap junction hemi-channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in gap junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in gap junction IEA
Inferred from Electronic Annotation
more info
  
located_in gap junction ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Innexin-6
NP_502435.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    12746584..12749721
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070034.5 → NP_502435.1  Innexin-6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502435.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q17395, Q9U3N4
    Conserved Domains (1) summary
    pfam00876
    Location:25 → 364
    Innexin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U3N4.1

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