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M02B1.3 TLC domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 178236, updated on 2-Nov-2024

Summary

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Official Symbol
M02B1.3
Official Full Name
TLC domain-containing protein
Primary source
WormBase:WBGene00010828
Locus tag
CELE_M02B1.3
See related
AllianceGenome:WB:WBGene00010828
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in several processes, including membrane assembly; phospholipid homeostasis; and regulation of membrane lipid distribution. Located in plasma membrane. Orthologous to human TLCD1 (TLC domain containing 1) and TLCD2 (TLC domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See M02B1.3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (12836508..12840411)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Cytohesin Ubiquitin Protein Inducing domain-containing protein;FERM domain-containing protein Neighboring gene Bax inhibitor-1 family protein Neighboring gene transcellular chaperone signaling (x)cross tissue Neighboring gene UDP-galactose/UDP-N-acetylglucosamine transporter srf-3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in membrane assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plasma membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of membrane lipid distribution IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TLC domain-containing protein
NP_001294011.1
  • Confirmed by transcript evidence
NP_502445.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    12836508..12840411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001307082.3 → NP_001294011.1  TLC domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294011.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061AD30
    Conserved Domains (1) summary
    smart00724
    Location:85 → 285
    TLC; TRAM, LAG1 and CLN8 homology domains

  2. NM_070044.7 → NP_502445.1  TLC domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502445.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q93892
    Conserved Domains (1) summary
    smart00724
    Location:85 → 285
    TLC; TRAM, LAG1 and CLN8 homology domains
Nucleotide Protein
Heading Accession and Version

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