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mbk-2 Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2;dual-specificity kinase [ Caenorhabditis elegans ]

Gene ID: 178250, updated on 17-Oct-2024

Summary

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Official Symbol
mbk-2
Official Full Name
Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2;dual-specificity kinase
Primary source
WormBase:WBGene00003150
Locus tag
CELE_F49E11.1
See related
AllianceGenome:WB:WBGene00003150
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in several processes, including P granule disassembly; asymmetric protein localization involved in cell fate determination; and protein phosphorylation. Located in several cellular components, including P granule; condensed chromosome; and microtubule cytoskeleton. Is expressed in several structures, including P0; body wall musculature; gonad; oocyte; and pharynx. Used to study Down syndrome. Orthologous to several human genes including DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See mbk-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
15
Sequence:
Chromosome: IV; NC_003282.8 (13009158..13035961)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene CUB-like domain-containing protein Neighboring gene ncRNA Neighboring gene CUB-like domain-containing protein;CUB_2 domain-containing protein Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene tRNA Neighboring gene tRNA Neighboring gene Putative ammonium transporter 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphorylation of the microtubule-severing AAA+ enzyme Katanin regulates C. elegans embryo development. Joly N, et al. J Cell Biol, 2020 Jun 1. PMID 32412594, Free PMC Article
  2. Identification of suppressors of mbk-2/DYRK by whole-genome sequencing. Wang Y, et al. G3 (Bethesda), 2014 Feb 19. PMID 24347622, Free PMC Article
  3. A high-content imaging approach to profile C. elegans embryonic development. Wang S, et al. Development, 2019 Apr 11. PMID 30890570, Free PMC Article
  4. Emerging role of DYRK family protein kinases as regulators of protein stability in cell cycle control. Becker W. Cell Cycle, 2012 Sep 15. PMID 22918246, Free PMC Article
  5. The oocyte-to-embryo transition. Robertson S, et al. Adv Exp Med Biol, 2013. PMID 22872483

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phosphorylation of the microtubule-severing AAA+ enzyme Katanin regulates C. elegans embryo development.
    Title: Phosphorylation of the microtubule-severing AAA+ enzyme Katanin regulates C. elegans embryo development.
  2. Phosphorylation by MBK-2 facilitates the binding of OMA proteins to TAF-4 and simultaneously inactivates their function in repressing zif-1 translation during the specification of primordial germ cells.
    Title: zif-1 translational repression defines a second, mutually exclusive OMA function in germline transcriptional repression.
  3. The pseudotyrosine phosphatases EGG-4 and EGG-5 sequester activated MBK-2 until the meiotic divisions by binding to the YTY motif and inhibiting MBK-2's kinase activity directly.
    Title: Regulation of MBK-2/DYRK by CDK-1 and the pseudophosphatases EGG-4 and EGG-5 during the oocyte-to-embryo transition.
  4. mbk-2 is essential in the zygote to ensure the postmeiotic inactivation of MEI-1 possibly via direct phosphorylation regulation
    Title: The mbk-2 kinase is required for inactivation of MEI-1/katanin in the one-cell Caenorhabditis elegans embryo.
  5. MBK-2 down-regulates the katanin-related protein MEI-1 to control spindle positioning and, through yet unknown factors, to control the localization of cytoplasmic determinants.
    Title: The minibrain kinase homolog, mbk-2, is required for spindle positioning and asymmetric cell division in early C. elegans embryos.
  6. MBK-2 directly phosphorylates MEI-1 and OMA-1 in vitro and that this activity is essential for their degradation in oocytes.
    Title: The C. elegans DYRK Kinase MBK-2 Marks Oocyte Proteins for Degradation in Response to Meiotic Maturation.
  7. MBK-2 functions as a temporal regulator of protein stability, and that coordinate activation of maternal protein degradation is one of the mechanisms that drives the transition from symmetric egg to patterned embryo.
    Title: Coordinate activation of maternal protein degradation during the egg-to-embryo transition in C. elegans.
  8. MBK-2 phosphorylates OMA-1 in vitro, primarily at threonine239; phosphorylation at T239 is required both for OMA-1 function in the 1-cell embryo and its degradation after the first mitosis
    Title: DYRK2 and GSK-3 phosphorylate and promote the timely degradation of OMA-1, a key regulator of the oocyte-to-embryo transition in C. elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in P granule disassembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in P granule disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in asymmetric protein localization involved in cell fate determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in P granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2;dual-specificity kinase
NP_001023207.1
  • Confirmed by transcript evidence
NP_001023208.1
  • Confirmed by transcript evidence
NP_001040950.1
  • Confirmed by transcript evidence
NP_001040951.1
  • Confirmed by transcript evidence
NP_001255695.1
  • Confirmed by transcript evidence
NP_001293914.1
  • Confirmed by transcript evidence
NP_001293915.1
  • Confirmed by transcript evidence
NP_001293916.1
  • Confirmed by transcript evidence
NP_001293917.1
  • Confirmed by transcript evidence
NP_001366773.1
  • Confirmed by transcript evidence
NP_001368118.1
  • Confirmed by transcript evidence
NP_001368149.1
  • Confirmed by transcript evidence
NP_001368473.1
  • Partially confirmed by transcript evidence
NP_001368474.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    13009158..13035961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001028037.4 → NP_001023208.1  Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023208.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XTF3
    Conserved Domains (2) summary
    smart00220
    Location:461 → 774
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14224
    Location:395 → 774
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

  2. NM_001028036.5 → NP_001023207.1  Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023207.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H9G2V8, H9G2V9, J7SF89, Q20604, Q27GP3, Q2EEP1, Q9TVF4, Q9XTF3
    Conserved Domains (2) summary
    smart00220
    Location:461 → 774
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14224
    Location:395 → 774
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

  3. NM_001306987.4 → NP_001293916.1  dual-specificity kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293916.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061AKR6
    Conserved Domains (1) summary
    cd14224
    Location:378 → 757
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

  4. NM_001380497.1 → NP_001368118.1  Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd14224
    Location:378 → 757
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

  5. NM_001306988.3 → NP_001293917.1  dual-specificity kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293917.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061ACN7
    Conserved Domains (1) summary
    cd14224
    Location:113 → 492
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

  6. NM_001380498.1 → NP_001368149.1  Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd14224
    Location:113 → 492
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

  7. NM_001047486.4 → NP_001040951.1  Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040951.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XTF3
    Conserved Domains (2) summary
    smart00220
    Location:160 → 473
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14224
    Location:94 → 473
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

  8. NM_001268766.4 → NP_001255695.1  Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255695.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XTF3
    Conserved Domains (2) summary
    smart00220
    Location:164 → 477
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14224
    Location:98 → 477
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

  9. NM_001380500.1 → NP_001366773.1  Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd14224
    Location:101 → 480
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

  10. NM_001306985.3 → NP_001293914.1  dual-specificity kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293914.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061ACK4
    Conserved Domains (1) summary
    cd14224
    Location:101 → 480
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

  11. NM_001380499.1 → NP_001368473.1  dual-specificity kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061ACN3
    Conserved Domains (1) summary
    cd14224
    Location:101 → 480
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

  12. NM_001306986.3 → NP_001293915.1  dual-specificity kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293915.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061AJ20
    Conserved Domains (1) summary
    cd14224
    Location:68 → 447
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

  13. NM_001380501.1 → NP_001368474.1  dual-specificity kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061ADU8
    Conserved Domains (1) summary
    cd14224
    Location:68 → 447
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

  14. NM_001047485.5 → NP_001040950.1  Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040950.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XTF3
    Conserved Domains (2) summary
    smart00220
    Location:134 → 447
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14224
    Location:68 → 447
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XTF3.1

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