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unc-26 Synaptojanin [ Caenorhabditis elegans ]

Gene ID: 178284, updated on 2-Nov-2024

Summary

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Official Symbol
unc-26
Official Full Name
Synaptojanin
Primary source
WormBase:WBGene00006763
Locus tag
CELE_JC8.10
See related
AllianceGenome:WB:WBGene00006763
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable inositol-1,4,5-trisphosphate 5-phosphatase activity; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in several processes, including acetylcholine transport; vesicle organization; and vesicle uncoating. Located in synapse. Is expressed in several structures, including intestine; nervous system; pharynx; tail; and vulval muscle. Used to study Down syndrome and early-onset Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 20; and developmental and epileptic encephalopathy 53. Orthologous to several human genes including SYNJ1 (synaptojanin 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-26 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
10
Sequence:
Chromosome: IV; NC_003282.8 (13261555..13272516, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Transthyretin-like family protein Neighboring gene Transmembrane protein Neighboring gene Transmembrane protein Neighboring gene Cleavage and polyadenylation specificity factor subunit 3 Neighboring gene C2H2-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and fine structure analysis of unc-26(IV) and adjacent regions in Caenorhabditis elegans. Charest DL, et al. Mol Gen Genet, 1990 May. PMID 2381425
  2. Mutations in synaptojanin disrupt synaptic vesicle recycling. Harris TW, et al. J Cell Biol, 2000 Aug 7. PMID 10931870, Free PMC Article
  3. Synaptojanin cooperates in vivo with endophilin through an unexpected mechanism. Dong Y, et al. Elife, 2015 Apr 28. PMID 25918845, Free PMC Article
  4. Endophilin is required for synaptic vesicle endocytosis by localizing synaptojanin. Schuske KR, et al. Neuron, 2003 Nov 13. PMID 14622579
  5. An economical and highly adaptable optogenetics system for individual and population-level manipulation of Caenorhabditis elegans. Koopman M, et al. BMC Biol, 2021 Aug 24. PMID 34429103, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol-1,4,5-trisphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Golgi vesicle uncoating IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in acetylcholine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in endosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gamma-aminobutyric acid transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in necroptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to synapse IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of backward locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of forward locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle uncoating IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Synaptojanin
NP_001023265.1
  • Confirmed by transcript evidence
NP_001023266.1
  • Confirmed by transcript evidence
NP_001122785.1
  • Confirmed by transcript evidence
NP_001129862.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    13261555..13272516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001028094.5 → NP_001023265.1  Synaptojanin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023265.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ECL2
    Conserved Domains (3) summary
    cd09089
    Location:521 → 829
    INPP5c_Synj; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanins
    pfam02383
    Location:60 → 336
    Syja_N; SacI homology domain
    cl17169
    Location:844 → 972
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_001028095.6 → NP_001023266.1  Synaptojanin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023266.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B3CJ53, G5ECL2, G5EDR8, G5EEJ9
    Conserved Domains (3) summary
    cd09089
    Location:527 → 835
    INPP5c_Synj; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanins
    pfam02383
    Location:60 → 336
    Syja_N; SacI homology domain
    cl17169
    Location:850 → 978
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. NM_001136390.4 → NP_001129862.1  Synaptojanin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129862.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ECL2
    Conserved Domains (1) summary
    pfam02383
    Location:60 → 336
    Syja_N; SacI homology domain

  4. NM_001129313.3 → NP_001122785.1  Synaptojanin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122785.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ECL2
    Conserved Domains (1) summary
    pfam02383
    Location:60 → 336
    Syja_N; SacI homology domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5ECL2.1

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