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Y67H2A.7 Peptidase M3A/M3B catalytic domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 178290, updated on 2-Nov-2024

Summary

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Official Symbol
Y67H2A.7
Official Full Name
Peptidase M3A/M3B catalytic domain-containing protein
Primary source
WormBase:WBGene00013464
Locus tag
CELE_Y67H2A.7
See related
AllianceGenome:WB:WBGene00013464
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in peptide metabolic process and protein processing involved in protein targeting to mitochondrion. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 31. Orthologous to human MIPEP (mitochondrial intermediate peptidase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See Y67H2A.7 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (13303742..13310823)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene KASH (Klarsicht/ANC-1/Syne Homology) Domain Protein Neighboring gene COP9 signalosome complex subunit 6 Neighboring gene Omega-3 fatty acid desaturase fat-1 Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein processing involved in protein targeting to mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Peptidase M3A/M3B catalytic domain-containing protein
NP_001380176.1
  • Confirmed by transcript evidence
NP_502558.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    13303742..13310823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392427.1 → NP_001380176.1  Peptidase M3A/M3B catalytic domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061ACY6
    Conserved Domains (1) summary
    cd06457
    Location:1 → 452
    M3A_MIP; Peptidase M3 mitochondrial intermediate peptidase (MIP)

  2. NM_070157.6 → NP_502558.2  Peptidase M3A/M3B catalytic domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502558.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95PY9
    Conserved Domains (1) summary
    cd06457
    Location:33 → 677
    M3A_MIP; Peptidase M3 mitochondrial intermediate peptidase (MIP)
Nucleotide Protein
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