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Y62E10A.13 Phosphoserine phosphatase [ Caenorhabditis elegans ]

Gene ID: 178304, updated on 2-Nov-2024

Summary

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Official Symbol
Y62E10A.13
Official Full Name
Phosphoserine phosphatase
Primary source
WormBase:WBGene00013379
Locus tag
CELE_Y62E10A.13
See related
AllianceGenome:WB:WBGene00013379
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable L-phosphoserine phosphatase activity and magnesium ion binding activity. Predicted to be involved in L-serine biosynthetic process. Predicted to be active in cytoplasm. Is expressed in head and intestine. Human ortholog(s) of this gene implicated in PSPH deficiency. Orthologous to human PSPH (phosphoserine phosphatase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See Y62E10A.13 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (13389146..13399053, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Mediator complex subunit 9 Neighboring gene Guanine nucleotide exchange factor MSS4 Neighboring gene U6 snRNA-associated Sm-like protein LSm3 Neighboring gene MEiosis-to-MItosis transition associated Neighboring gene CYtochrome P450 family Neighboring gene Neuropeptide-Like Protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
  2. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables L-phosphoserine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-phosphoserine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-serine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-serine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Phosphoserine phosphatase
NP_001041052.2
  • Confirmed by transcript evidence
NP_001293892.1
  • Confirmed by transcript evidence
NP_001293893.1
  • Confirmed by transcript evidence
NP_001293894.1
  • Confirmed by transcript evidence
NP_001293895.1
  • Confirmed by transcript evidence
NP_001359637.1
  • Confirmed by transcript evidence
NP_502580.2
  • Confirmed by transcript evidence
NP_502581.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    13389146..13399053 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001306966.2 → NP_001293895.1  Phosphoserine phosphatase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293895.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061ACH4
    Conserved Domains (2) summary
    PLN02954
    Location:31 → 254
    PLN02954; phosphoserine phosphatase
    pfam00702
    Location:41 → 216
    Hydrolase; haloacid dehalogenase-like hydrolase

  2. NM_070179.7 → NP_502580.2  Phosphoserine phosphatase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502580.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U1W6
    Conserved Domains (2) summary
    PLN02954
    Location:44 → 267
    PLN02954; phosphoserine phosphatase
    pfam00702
    Location:54 → 229
    Hydrolase; haloacid dehalogenase-like hydrolase

  3. NM_070180.4 → NP_502581.2  Phosphoserine phosphatase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502581.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U1W7
    Conserved Domains (2) summary
    PLN02954
    Location:47 → 270
    PLN02954; phosphoserine phosphatase
    pfam00702
    Location:57 → 232
    Hydrolase; haloacid dehalogenase-like hydrolase

  4. NM_001372954.2 → NP_001359637.1  Phosphoserine phosphatase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95Q10
    Conserved Domains (1) summary
    cd04309
    Location:41 → 248
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  5. NM_001306965.3 → NP_001293894.1  Phosphoserine phosphatase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293894.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061ADS3
    Conserved Domains (2) summary
    PLN02954
    Location:53 → 276
    PLN02954; phosphoserine phosphatase
    pfam00702
    Location:63 → 238
    Hydrolase; haloacid dehalogenase-like hydrolase

  6. NM_001306963.3 → NP_001293892.1  Phosphoserine phosphatase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293892.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061AKN1
    Conserved Domains (2) summary
    PLN02954
    Location:47 → 272
    PLN02954; phosphoserine phosphatase
    pfam00702
    Location:57 → 234
    Hydrolase; haloacid dehalogenase-like hydrolase

  7. NM_001306964.3 → NP_001293893.1  Phosphoserine phosphatase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293893.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061ACK7
    Conserved Domains (2) summary
    PLN02954
    Location:53 → 278
    PLN02954; phosphoserine phosphatase
    pfam00702
    Location:63 → 240
    Hydrolase; haloacid dehalogenase-like hydrolase

  8. NM_001047587.4 → NP_001041052.2  Phosphoserine phosphatase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041052.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3NQB6
    Conserved Domains (1) summary
    cl21460
    Location:2 → 57
    HAD_like; Haloacid Dehalogenase-like Hydrolases
Nucleotide Protein
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