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ugt-22 UDP-glucuronosyltransferase [ Caenorhabditis elegans ]

Gene ID: 178330, updated on 2-Nov-2024

Summary

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Official Symbol
ugt-22
Official Full Name
UDP-glucuronosyltransferase
Primary source
WormBase:WBGene00007455
Locus tag
CELE_C08F11.8
See related
AllianceGenome:WB:WBGene00007455
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Orthologous to human UGT3A1 (UDP glycosyltransferase family 3 member A1) and UGT3A2 (UDP glycosyltransferase family 3 member A2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ugt-22 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
10
Sequence:
Chromosome: IV; NC_003282.8 (13639260..13644402)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene SPK domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class Z Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The transcription factor SKN-1 and detoxification gene ugt-22 alter albendazole efficacy in Caenorhabditis elegans. Fontaine P, et al. Int J Parasitol Drugs Drug Resist, 2018 Aug. PMID 29793058, Free PMC Article
  2. Multiple UDP glycosyltransferases modulate benzimidazole drug sensitivity in the nematode Caenorhabditis elegans in an additive manner. Sharma N, et al. Int J Parasitol, 2024 Sep. PMID 38806068
  3. Stress response pathways protect germ cells from omega-6 polyunsaturated fatty acid-mediated toxicity in Caenorhabditis elegans. Webster CM, et al. Dev Biol, 2013 Jan 1. PMID 23064027, Free PMC Article
  4. An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans. Budovskaya YV, et al. Cell, 2008 Jul 25. PMID 18662544, Free PMC Article
  5. UDP-glycosyltransferase family in Haemonchus contortus: Phylogenetic analysis, constitutive expression, sex-differences and resistance-related differences. Matoušková P, et al. Int J Parasitol Drugs Drug Resist, 2018 Dec. PMID 30293057, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables UDP-glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucuronosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UDP-glucuronosyltransferase
NP_502633.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    13639260..13644402
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070232.6 → NP_502633.1  UDP-glucuronosyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502633.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U3Q6
    Conserved Domains (2) summary
    PHA03392
    Location:256 → 515
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:36 → 530
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
Nucleotide Protein
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