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iscu-1 NIF system FeS cluster assembly NifU N-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 178344, updated on 2-Nov-2024

Summary

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Official Symbol
iscu-1
Official Full Name
NIF system FeS cluster assembly NifU N-terminal domain-containing protein
Primary source
WormBase:WBGene00012885
Locus tag
CELE_Y45F10D.4
See related
AllianceGenome:WB:WBGene00012885
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 2 iron, 2 sulfur cluster binding activity and ferrous iron binding activity. Predicted to be involved in intracellular iron ion homeostasis. Predicted to be active in mitochondrial matrix. Is expressed in body wall musculature; hypodermis; and intestine. Orthologous to human ISCU (iron-sulfur cluster assembly enzyme). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See iscu-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (13783962..13784680)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Large ribosomal subunit protein eL18 Neighboring gene Putative polypeptide N-acetylgalactosaminyltransferase 10;Ricin B lectin domain-containing protein Neighboring gene Beta-lactamase-related domain-containing protein Neighboring gene Integrin Cytoplasmic domain-Associated Protein homolog Neighboring gene Spindle assembly abnormal protein 6 Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Selection of reliable reference genes for gene expression studies in Caenorhabditis elegans exposed to crystals (Cry1Ia36) protein of Bacillus thuringiensis. Wang D, et al. Mol Biol Rep, 2019 Dec. PMID 31385235
  2. A novel role of the mitochondrial iron-sulfur cluster assembly protein ISCU-1/ISCU in longevity and stress response. Sheng Y, et al. Geroscience, 2021 Apr. PMID 33527323, Free PMC Article
  3. Determination of reliable reference genes for multi-generational gene expression analysis on C. elegans exposed to abused drug nicotine. Taki FA, et al. Psychopharmacology (Berl), 2013 Nov. PMID 23681163, Free PMC Article
  4. Maackiain Mimics Caloric Restriction through aak-2-Mediated Lipid Reduction in Caenorhabditis elegans. Mladenova SG, et al. Int J Mol Sci, 2023 Dec 13. PMID 38139270, Free PMC Article
  5. Evaluation and normalization of a set of reliable reference genes for quantitative sgk-1 gene expression analysis in Caenorhabditis elegans-focused cancer research. Özdemir ÖÜ, et al. Nucleosides Nucleotides Nucleic Acids, 2024 Feb 15. PMID 38359339

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular iron ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron-sulfur cluster assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NIF system FeS cluster assembly NifU N-terminal domain-containing protein
NP_502658.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    13783962..13784680
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070257.4 → NP_502658.1  NIF system FeS cluster assembly NifU N-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502658.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O45948
    Conserved Domains (1) summary
    PRK11325
    Location:27 → 151
    PRK11325; scaffold protein; Provisional
Nucleotide Protein
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