prdh-1 Proline dehydrogenase 1, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: prdh-1
Official Full Name: Proline dehydrogenase 1, mitochondrial
Primary source: WormBase:WBGene00007197
Locus tag: CELE_B0513.5
See related: AllianceGenome:WB:WBGene00007197
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable FAD binding activity and proline dehydrogenase activity. Predicted to be involved in proline catabolic process to glutamate. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in amino acid metabolic disorder; hyperprolinemia type 1; and schizophrenia 4. Orthologous to several human genes including PRODH (proline dehydrogenase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See prdh-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 9

Sequence:: Chromosome: IV; NC_003282.8 (13868556..13876615, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0513.5 (e-PCR)
- UniSTS:307191

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables FAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables FAD binding	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables proline dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables proline dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables proline dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in proline catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proline catabolic process to glutamate	IBA Inferred from Biological aspect of Ancestor more info
involved_in proline catabolic process to glutamate	IEA Inferred from Electronic Annotation more info
involved_in proline metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Proline dehydrogenase 1, mitochondrial

NP_001368485.1

Confirmed by transcript evidence

NP_502669.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

13868556..13876615 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_070268.7 → NP_502669.2 Proline dehydrogenase 1, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502669.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A061AD41, O45228

Conserved Domains (3) summary

PLN02681
Location:58 → 604

PLN02681; proline dehydrogenase

pfam01619
Location:347 → 592

Pro_dh; Proline dehydrogenase

cl08302
Location:285 → 325

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
NM_001380524.1 → NP_001368485.1 Proline dehydrogenase 1, mitochondrial [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

PLN02681
Location:2 → 503

PLN02681; proline dehydrogenase