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cfp-1 CXXC-type zinc finger protein 1 [ Caenorhabditis elegans ]

Gene ID: 178363, updated on 2-Nov-2024

Summary

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Official Symbol
cfp-1
Official Full Name
CXXC-type zinc finger protein 1
Primary source
WormBase:WBGene00009924
Locus tag
CELE_F52B11.1
See related
AllianceGenome:WB:WBGene00009924
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable methylated histone binding activity. Involved in transdifferentiation. Predicted to be located in nucleus. Predicted to be part of Set1C/COMPASS complex. Orthologous to human CXXC1 (CXXC finger protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cfp-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (14077441..14083559)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene PX domain-containing protein;Sorting nexin lst-4 Neighboring gene DBC1/CARP1 catalytically inactive NUDIX hydrolase domain-containing protein;SAP domain-containing protein Neighboring gene putative phosphomannomutase Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Extreme HOT regions are CpG-dense promoters in C. elegans and humans. Chen RA, et al. Genome Res, 2014 Jul. PMID 24653213, Free PMC Article
  2. Conserved dual-mode gene regulation programs in higher eukaryotes. Lee JY, et al. Nucleic Acids Res, 2021 Mar 18. PMID 33621342, Free PMC Article
  3. A Role for Caenorhabditis elegans COMPASS in Germline Chromatin Organization. Herbette M, et al. Cells, 2020 Sep 8. PMID 32911802, Free PMC Article
  4. Loss of SET1/COMPASS methyltransferase activity reduces lifespan and fertility in Caenorhabditis elegans. Caron M, et al. Life Sci Alliance, 2022 Mar. PMID 34893559, Free PMC Article
  5. CFP-1 interacts with HDAC1/2 complexes in C. elegans development. Pokhrel B, et al. FEBS J, 2019 Jul. PMID 30941832

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Post-transcriptional repression of CFP-1 expands the regulatory repertoire of LIN-41/TRIM71.
    Title: Post-transcriptional repression of CFP-1 expands the regulatory repertoire of LIN-41/TRIM71.
  2. CFP-1 is required for fertility and normal growth rate. CFP-1 genetically interacts with HDAC1/2.
    Title: CFP-1 interacts with HDAC1/2 complexes in C. elegans development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transdifferentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Set1C/COMPASS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Set1C/COMPASS complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CXXC-type zinc finger protein 1
NP_001255784.1
  • Confirmed by transcript evidence
NP_001255785.1
  • Confirmed by transcript evidence
NP_001367055.1
  • Confirmed by transcript evidence
NP_001367237.1
  • Confirmed by transcript evidence
NP_001367271.1
  • Confirmed by transcript evidence
NP_001367272.1
  • Confirmed by transcript evidence
NP_001379228.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    14077441..14083559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392439.1 → NP_001379228.1  CXXC-type zinc finger protein 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3YT77, E3W754, E3W755, E3W756, E3W757, Q86D13, Q9XUE7
    Conserved Domains (1) summary
    pfam12269
    Location:188 → 435
    zf-CpG_bind_C; CpG binding protein zinc finger C terminal domain

  2. NM_001380528.2 → NP_001367055.1  CXXC-type zinc finger protein 1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    pfam12269
    Location:69 → 316
    zf-CpG_bind_C; CpG binding protein zinc finger C terminal domain

  3. NM_001380529.1 → NP_001367271.1  CXXC-type zinc finger protein 1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    pfam12269
    Location:120 → 367
    zf-CpG_bind_C; CpG binding protein zinc finger C terminal domain

  4. NM_001380530.1 → NP_001367237.1  CXXC-type zinc finger protein 1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    pfam12269
    Location:1 → 248
    zf-CpG_bind_C; CpG binding protein zinc finger C terminal domain

  5. NM_001380531.1 → NP_001367272.1  CXXC-type zinc finger protein 1 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    pfam12269
    Location:2 → 125
    zf-CpG_bind_C; CpG binding protein zinc finger C terminal domain

  6. NM_001268855.3 → NP_001255784.1  CXXC-type zinc finger protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255784.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E3W756
    Conserved Domains (1) summary
    pfam12269
    Location:1 → 25
    zf-CpG_bind_C; CpG binding protein zinc finger C terminal domain

  7. NM_001268856.3 → NP_001255785.1  CXXC-type zinc finger protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255785.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E3W757
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XUE7.3

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