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qars-1 Glutaminyl-tRNA synthetase;Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding domain-containing protein;glutamine--tRNA ligase;putative glutamine--tRNA ligase [ Caenorhabditis elegans ]

Gene ID: 178415, updated on 2-Nov-2024

Summary

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Official Symbol
qars-1
Official Full Name
Glutaminyl-tRNA synthetase;Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding domain-containing protein;glutamine--tRNA ligase;putative glutamine--tRNA ligase
Primary source
WormBase:WBGene00001336
Locus tag
CELE_Y41E3.4
See related
AllianceGenome:WB:WBGene00001336
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glutamine-tRNA ligase activity. Predicted to be involved in glutaminyl-tRNA aminoacylation. Predicted to be located in cytoplasm. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Predicted to be active in cytosol. Orthologous to human QARS1 (glutaminyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See qars-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (15008503..15013183, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene DUF4440 domain-containing protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ACB domain-containing protein;GOLD domain-containing protein;Golgi resident protein GCP60 Neighboring gene FANCD2 Neighboring gene Glycine Rich Secreted Protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure networks of E. coli glutaminyl-tRNA synthetase: effects of ligand binding. Sathyapriya R, et al. Proteins, 2007 Aug 1. PMID 17444518
  2. Salmonella enterica Serovar Typhi exposure elicits deliberate physiological alterations and triggers the involvement of ubiquitin mediated proteolysis pathway in Caenorhabditis elegans. Balasubramaniam B, et al. Int J Biol Macromol, 2020 Apr 15. PMID 31987945
  3. Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. Simmer F, et al. PLoS Biol, 2003 Oct. PMID 14551910, Free PMC Article
  4. Caenorhabditis elegans evolves a new architecture for the multi-aminoacyl-tRNA synthetase complex. Havrylenko S, et al. J Biol Chem, 2011 Aug 12. PMID 21685384, Free PMC Article
  5. A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large. Waaijers S, et al. BMC Biol, 2016 Aug 9. PMID 27506200, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutaminyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutaminyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of aminoacyl-tRNA synthetase multienzyme complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Glutaminyl-tRNA synthetase;Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding domain-containing protein;glutamine--tRNA ligase;putative glutamine--tRNA ligase
NP_001255843.1
  • Confirmed by transcript evidence
NP_001255844.1
  • Confirmed by transcript evidence
NP_001255845.1
  • Confirmed by transcript evidence
NP_001263821.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    15008503..15013183 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268914.5 → NP_001255843.1  putative glutamine--tRNA ligase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255843.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O62431
    Conserved Domains (5) summary
    PLN02859
    Location:1 → 785
    PLN02859; glutamine-tRNA ligase
    cd00807
    Location:269 → 573
    GlnRS_core; catalytic core domain of glutaminyl-tRNA synthetase
    pfam03950
    Location:571 → 761
    tRNA-synt_1c_C; tRNA synthetases class I (E and Q), anti-codon binding domain
    pfam04557
    Location:162 → 262
    tRNA_synt_1c_R2; Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
    pfam04558
    Location:7 → 159
    tRNA_synt_1c_R1; Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1

  2. NM_001276892.4 → NP_001263821.1  Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263821.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    I2HAI0
    Conserved Domains (1) summary
    PRK05347
    Location:1 → 205
    PRK05347; glutaminyl-tRNA synthetase; Provisional

  3. NM_001268915.3 → NP_001255844.1  glutamine--tRNA ligase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255844.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3YT95
    Conserved Domains (4) summary
    cd00807
    Location:43 → 347
    GlnRS_core; catalytic core domain of glutaminyl-tRNA synthetase
    PRK05347
    Location:42 → 553
    PRK05347; glutaminyl-tRNA synthetase; Provisional
    pfam03950
    Location:345 → 535
    tRNA-synt_1c_C; tRNA synthetases class I (E and Q), anti-codon binding domain
    pfam04557
    Location:1 → 36
    tRNA_synt_1c_R2; Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2

  4. NM_001268916.3 → NP_001255845.1  Glutaminyl-tRNA synthetase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255845.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3YT96
    Conserved Domains (2) summary
    pfam03950
    Location:201 → 391
    tRNA-synt_1c_C; tRNA synthetases class I (E and Q), anti-codon binding domain
    cl00015
    Location:58 → 203
    nt_trans; nucleotidyl transferase superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O62431.1

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