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eef-1B.2 putative elongation factor 1-beta/1-delta 2 [ Caenorhabditis elegans ]

Gene ID: 178419, updated on 2-Nov-2024

Summary

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Official Symbol
eef-1B.2
Official Full Name
putative elongation factor 1-beta/1-delta 2
Primary source
WormBase:WBGene00012768
Locus tag
CELE_Y41E3.10
See related
AllianceGenome:WB:WBGene00012768
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in translational elongation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation elongation factor 1 complex. Predicted to be active in cytosol. Orthologous to several human genes including EEF1B2 (eukaryotic translation elongation factor 1 beta 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See eef-1B.2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (15037331..15039551)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene FANCD2 Neighboring gene Glycine Rich Secreted Protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene B30.2/SPRY domain-containing protein Neighboring gene Serpentine Receptor, class T Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans. Son HG, et al. Genes Dev, 2018 Dec 1. PMID 30478249, Free PMC Article
  2. Reduction of mRNA export unmasks different tissue sensitivities to low mRNA levels during Caenorhabditis elegans development. Zheleva A, et al. PLoS Genet, 2019 Sep. PMID 31525188, Free PMC Article
  3. A UPR-independent infection-specific role for a BiP/GRP78 protein in the control of antimicrobial peptide expression in C. elegans epidermis. Couillault C, et al. Virulence, 2012 May 1. PMID 22546897, Free PMC Article
  4. Mechanism and regulation of translation in C. elegans. Rhoads RE, et al. WormBook, 2006 Jan 28. PMID 18050488, Free PMC Article
  5. SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells. Jackson J, et al. Mol Metab, 2022 Jul. PMID 35452878, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA (uridine-N3-)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in rRNA base methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational elongation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation elongation factor 1 complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative elongation factor 1-beta/1-delta 2
NP_001122811.1
  • Confirmed by transcript evidence
NP_502816.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    15037331..15039551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001129339.2 → NP_001122811.1  putative elongation factor 1-beta/1-delta 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122811.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U2H9
    Conserved Domains (2) summary
    pfam10354
    Location:122 → 294
    DUF2431; Domain of unknown function (DUF2431)
    cl00518
    Location:388 → 439
    Asp_Glu_race; Asp/Glu/Hydantoin racemase

  2. NM_070415.6 → NP_502816.2  putative elongation factor 1-beta/1-delta 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502816.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A3RMU4, H9G359, H9G360, Q9U2H9
    Conserved Domains (1) summary
    pfam00736
    Location:179 → 263
    EF1_GNE; EF-1 guanine nucleotide exchange domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U2H9.4

Gene LinkOut

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