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ari-1.4 Ariadne domain-containing protein;RBR-type E3 ubiquitin transferase [ Caenorhabditis elegans ]

Gene ID: 178437, updated on 2-Nov-2024

Summary

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Official Symbol
ari-1.4
Official Full Name
Ariadne domain-containing protein;RBR-type E3 ubiquitin transferase
Primary source
WormBase:WBGene00013538
Locus tag
CELE_Y73F8A.34
See related
AllianceGenome:WB:WBGene00013538
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in intestine and nervous system. Orthologous to human ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ari-1.4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (15524092..15528528, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene pseudo Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ARI-1, an RBR family ubiquitin-ligase, functions with UBC-18 to regulate pharyngeal development in C. elegans. Qiu X, et al. Dev Biol, 2006 Mar 15. PMID 16457801
  2. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ariadne domain-containing protein;RBR-type E3 ubiquitin transferase
NP_001041060.1
  • Confirmed by transcript evidence
NP_001041061.1
  • Partially confirmed by transcript evidence
NP_001255868.1
  • Confirmed by transcript evidence
NP_001255869.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    15524092..15528528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001047595.3 → NP_001041060.1  RBR-type E3 ubiquitin transferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041060.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NA31
    Conserved Domains (2) summary
    smart00647
    Location:193 → 252
    IBR; In Between Ring fingers
    pfam01485
    Location:273 → 314
    IBR; IBR domain, a half RING-finger domain

  2. NM_001268940.3 → NP_001255869.1  RBR-type E3 ubiquitin transferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255869.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3NQB5
    Conserved Domains (2) summary
    smart00647
    Location:13 → 72
    IBR; In Between Ring fingers
    pfam01485
    Location:93 → 134
    IBR; IBR domain, a half RING-finger domain

  3. NM_001268939.3 → NP_001255868.1  RBR-type E3 ubiquitin transferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255868.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3NQB4
    Conserved Domains (2) summary
    smart00647
    Location:144 → 203
    IBR; In Between Ring fingers
    pfam01485
    Location:224 → 265
    IBR; IBR domain, a half RING-finger domain

  4. NM_001047596.4 → NP_001041061.1  Ariadne domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041061.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2HQK5
Nucleotide Protein
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