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set-26 Histone-lysine N-methyltransferase set-26 [ Caenorhabditis elegans ]

Gene ID: 178463, updated on 2-Nov-2024

Summary

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Official Symbol
set-26
Official Full Name
Histone-lysine N-methyltransferase set-26
Primary source
WormBase:WBGene00013106
Locus tag
CELE_Y51H4A.12
See related
AllianceGenome:WB:WBGene00013106
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables histone H3K9 methyltransferase activity. Predicted to be involved in chromatin remodeling and methylation. Predicted to be active in nucleus. Is expressed in several structures, including germ cell; germ line; intestine; muscle cell; and somatic cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See set-26 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
9
Sequence:
Chromosome: IV; NC_003282.8 (16646791..16655883, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RNase NYN domain-containing protein Neighboring gene Pre-rRNA-processing protein TSR2 homolog Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity. Wang W, et al. Elife, 2018 May 1. PMID 29714684, Free PMC Article
  2. Two SET domain containing genes link epigenetic changes and aging in Caenorhabditis elegans. Ni Z, et al. Aging Cell, 2012 Apr. PMID 22212395, Free PMC Article
  3. Characterization of the distribution and dynamics of chromatin states in the C. elegans germline reveals substantial H3K4me3 remodeling during oogenesis. Mazzetto M, et al. Genome Res, 2024 Feb 7. PMID 38164610, Free PMC Article
  4. SUMOylation of the chromodomain factor MRG-1 in C. elegans affects chromatin-regulatory dynamics. Baytek G, et al. Biotechniques, 2022 Jun. PMID 35698829
  5. A histone methylation network regulates transgenerational epigenetic memory in C. elegans. Greer EL, et al. Cell Rep, 2014 Apr 10. PMID 24685137, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in C. elegans.
    Title: The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in C. elegans.
  2. found that set-9 and set-26 partially act through the Forkhead box O (FOXO) transcription factor, DAF-16, to modulate lifespan
    Title: Two SET domain containing genes link epigenetic changes and aging in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables histone H3K9 methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K9 trimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Histone-lysine N-methyltransferase set-26
NP_001370101.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    16646791..16655883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383260.2 → NP_001370101.1  Histone-lysine N-methyltransferase set-26 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U263
    Conserved Domains (3) summary
    PRK03427
    Location:9 → 135
    PRK03427; cell division protein ZipA; Provisional
    cd15570
    Location:796 → 839
    PHD_Bye1p_SIZ1_like; PHD domain found in Saccharomyces cerevisiae bypass of ESS1 protein 1 (Bye1p), the E3 Sumo Ligase SIZ1, and similar proteins
    cd10529
    Location:935 → 1067
    SET_SETD5-like; SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U263.3

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