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sta-1 Signal transducer and activator of transcription 1 [ Caenorhabditis elegans ]

Gene ID: 178465, updated on 2-Nov-2024

Summary

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Official Symbol
sta-1
Official Full Name
Signal transducer and activator of transcription 1
Primary source
WormBase:WBGene00013111
Locus tag
CELE_Y51H4A.17
See related
AllianceGenome:WB:WBGene00013111
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables sequence-specific DNA binding activity. Involved in dauer larval development and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including anal depressor muscle; body wall musculature; coelomocyte; intestine; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); breast cancer (multiple); carcinoma (multiple); reproductive organ cancer (multiple); and scleroderma (multiple). Orthologous to several human genes including STAT5A (signal transducer and activator of transcription 5A) and STAT5B (signal transducer and activator of transcription 5B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sta-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (16664320..16671472)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Gly Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. sta-1 is repressed by mir-58 family in Caenorhabditis elegans. Lozano E, et al. Worm, 2016. PMID 28090395, Free PMC Article
  2. C. elegans STAT: evolution of a regulatory switch. Wang Y, et al. FASEB J, 2006 Aug. PMID 16873887
  3. An Alternative STAT Signaling Pathway Acts in Viral Immunity in Caenorhabditis elegans. Tanguy M, et al. mBio, 2017 Sep 5. PMID 28874466, Free PMC Article
  4. Dissection of lin-11 enhancer regions in Caenorhabditis elegans and other nematodes. Marri S, et al. Dev Biol, 2009 Jan 15. PMID 18950616
  5. Surveillance Immunity: An Emerging Paradigm of Innate Defense Activation in Caenorhabditis elegans. Pukkila-Worley R. PLoS Pathog, 2016 Sep. PMID 27631629, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. findings show the STAT homolog STA-1 orchestrates antiviral immunity
    Title: An Alternative STAT Signaling Pathway Acts in Viral Immunity in Caenorhabditis elegans.
  2. DNA binding is not a necessary prerequisite for nuclear retention of activated STAT proteins
    Title: C. elegans STAT: evolution of a regulatory switch.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dauer larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dauer larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Signal transducer and activator of transcription 1
NP_001122814.1
  • Confirmed by transcript evidence
NP_001122815.1
  • Confirmed by transcript evidence
NP_502974.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    16664320..16671472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070573.6 → NP_502974.2  Signal transducer and activator of transcription 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502974.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A5HWB4, Q29TW4, Q9NAD6
    Conserved Domains (3) summary
    cd09919
    Location:457 → 574
    SH2_STAT_family; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) family
    pfam01017
    Location:7 → 196
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:199 → 466
    STAT_bind; STAT protein, DNA binding domain

  2. NM_001129343.3 → NP_001122815.1  Signal transducer and activator of transcription 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122815.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NAD6
    Conserved Domains (3) summary
    cd09919
    Location:457 → 574
    SH2_STAT_family; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) family
    pfam01017
    Location:7 → 196
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:199 → 466
    STAT_bind; STAT protein, DNA binding domain

  3. NM_001129342.4 → NP_001122814.1  Signal transducer and activator of transcription 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122814.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NAD6
    Conserved Domains (3) summary
    cd09919
    Location:457 → 553
    SH2_STAT_family; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) family
    pfam01017
    Location:7 → 196
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:199 → 466
    STAT_bind; STAT protein, DNA binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NAD6.2

Gene LinkOut

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