nra-1 Nicotinic receptor-associated protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nra-1
Official Full Name: Nicotinic receptor-associated protein 1
Primary source: WormBase:WBGene00012128
Locus tag: CELE_T28F3.1
See related: AllianceGenome:WB:WBGene00012128
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable calcium-dependent phospholipid binding activity. Involved in receptor localization to synapse. Located in plasma membrane. Is expressed in body wall musculature; head neurons; tail neurons; and ventral cord neurons. Orthologous to several human genes including CPNE5 (copine 5) and CPNE9 (copine family member 9). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nra-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 9

Sequence:: Chromosome: IV; NC_003282.8 (17281455..17284199, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F26D10.4 (e-PCR)
- UniSTS:321406

T28F3.1 (e-PCR)
- UniSTS:312794

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to calcium ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor localization to synapse	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nicotinic receptor-associated protein 1

NP_503069.1

Confirmed by transcript evidence

NP_872104.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

17281455..17284199 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_070668.6 → NP_503069.1 Nicotinic receptor-associated protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_503069.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8I4F4, Q9XUB9

Conserved Domains (3) summary

cd04047
Location:174 → 297

C2B_Copine; C2 domain second repeat in Copine

cd04048
Location:15 → 149

C2A_Copine; C2 domain first repeat in Copine

cd01459
Location:310 → 569

vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...
NM_182304.4 → NP_872104.1 Nicotinic receptor-associated protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_872104.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9XUB9

Conserved Domains (3) summary

cd04047
Location:174 → 285

C2B_Copine; C2 domain second repeat in Copine

cd04048
Location:15 → 149

C2A_Copine; C2 domain first repeat in Copine

cd01459
Location:298 → 557

vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...