dlat-2 2-oxoacid dehydrogenase acyltransferase catalytic domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dlat-2
Official Full Name: 2-oxoacid dehydrogenase acyltransferase catalytic domain-containing protein
Primary source: WormBase:WBGene00007824
Locus tag: CELE_C30H6.7
See related: AllianceGenome:WB:WBGene00007824
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable dihydrolipoyllysine-residue acetyltransferase activity. Predicted to be involved in acetyl-CoA biosynthetic process from pyruvate. Predicted to be part of pyruvate dehydrogenase complex. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency and sarcoma. Orthologous to human PDHX (pyruvate dehydrogenase complex component X). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dlat-2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (17380626..17382225)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C30H6.9 (e-PCR)
- UniSTS:320860

C30H6.7 (e-PCR)
- UniSTS:306044

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables dihydrolipoyllysine-residue acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in acetyl-CoA biosynthetic process from pyruvate	IBA Inferred from Biological aspect of Ancestor more info
involved_in acetyl-CoA biosynthetic process from pyruvate	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of pyruvate dehydrogenase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of pyruvate dehydrogenase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 2-oxoacid dehydrogenase acyltransferase catalytic domain-containing protein

NP_001255950.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

17380626..17382225

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001269021.5 → NP_001255950.1 2-oxoacid dehydrogenase acyltransferase catalytic domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255950.1

Status: REVIEWED

UniProtKB/TrEMBL

O45279

Conserved Domains (2) summary

pfam00198
Location:98 → 321

2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)

pfam02817
Location:23 → 54

E3_binding; e3 binding domain