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gba-3 Putative glucosylceramidase 3 [ Caenorhabditis elegans ]

Gene ID: 178535, updated on 2-Nov-2024

Summary

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Official Symbol
gba-3
Official Full Name
Putative glucosylceramidase 3
Primary source
WormBase:WBGene00008706
Locus tag
CELE_F11E6.1
See related
AllianceGenome:WB:WBGene00008706
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable glucosylceramidase activity. Predicted to be involved in glucosylceramide catabolic process. Human ortholog(s) of this gene implicated in Gaucher's disease (multiple); Lewy body dementia; Parkinson's disease (multiple); and Parkinsonism. Orthologous to human GBA1 (glucosylceramidase beta 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gba-3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
9
Sequence:
Chromosome: IV; NC_003282.8 (17473334..17479397)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Ascaris suum EPICuticlin protein related Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TransThyretin-Related family domain Neighboring gene ncRNA Neighboring gene Ground-like domain-containing protein Neighboring gene ncRNA Neighboring gene Ras-related protein Rab-44 Neighboring gene ncRNA Neighboring gene Metalloendopeptidase;Zinc metalloproteinase nas-6 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Subcellular Nanorheology Reveals Lysosomal Viscosity as a Reporter for Lysosomal Storage Diseases. Devany J, et al. Nano Lett, 2018 Feb 14. PMID 29313356
  2. Degradation of hexosylceramides is required for timely corpse clearance via formation of cargo-containing phagolysosomal vesicles. Holzapfel R, et al. Eur J Cell Biol, 2024 Jun. PMID 38582051
  3. A DNA nanodevice for mapping sodium at single-organelle resolution. Zou J, et al. Nat Biotechnol, 2024 Jul. PMID 37735265, Free PMC Article
  4. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article
  5. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables glucosylceramidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucosylceramidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glucosylceramide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Putative glucosylceramidase 3
NP_001255965.1
  • Confirmed by transcript evidence
NP_503118.1
  • Confirmed by transcript evidence
NP_503119.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    17473334..17479397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269036.3 → NP_001255965.1  Putative glucosylceramidase 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255965.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ECR8
    Conserved Domains (1) summary
    cl23815
    Location:28 → 521
    Glyco_hydro_30; O-Glycosyl hydrolase family 30

  2. NM_070717.4 → NP_503118.1  Putative glucosylceramidase 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503118.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ECR8
    Conserved Domains (1) summary
    cl23815
    Location:25 → 518
    Glyco_hydro_30; O-Glycosyl hydrolase family 30

  3. NM_070718.4 → NP_503119.1  Putative glucosylceramidase 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503119.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5ECR8, G5EEA6, G5EFK0, Q8MQ76
    Conserved Domains (1) summary
    cl23815
    Location:25 → 518
    Glyco_hydro_30; O-Glycosyl hydrolase family 30

RNA

  1. NR_132469.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5ECR8.1

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