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egl-8 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8;Phosphoinositide phospholipase C [ Caenorhabditis elegans ]

Gene ID: 178537, updated on 2-Nov-2024

Summary

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Official Symbol
egl-8
Official Full Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8;Phosphoinositide phospholipase C
Primary source
WormBase:WBGene00001177
Locus tag
CELE_B0348.4
See related
AllianceGenome:WB:WBGene00001177
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphatidylinositol phospholipase C activity. Involved in several processes, including G protein-coupled dopamine receptor signaling pathway; positive regulation of acetylcholine secretion, neurotransmission; and thermotaxis. Located in plasma membrane. Is expressed in intestine; nervous system; non-striated muscle; and vas deferens. Used to study nicotine dependence. Orthologous to human PLCB4 (phospholipase C beta 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See egl-8 in Genome Data Viewer
Location:
chromosome: V
Exon count:
23
Sequence:
Chromosome: V; NC_003283.11 (20818..43704)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene LITAF domain-containing protein Neighboring gene LITAF domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence for a role for cyclic AMP in modulating the action of 5-HT and an excitatory neuropeptide, FLP17A, in the pharyngeal muscle of Caenorhabditis elegans. Papaioannou S, et al. Invert Neurosci, 2008 Jun. PMID 18463910
  2. Facilitation of synaptic transmission by EGL-30 Gqalpha and EGL-8 PLCbeta: DAG binding to UNC-13 is required to stimulate acetylcholine release. Lackner MR, et al. Neuron, 1999 Oct. PMID 10571228
  3. Krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging. SenGupta T, et al. Aging (Albany NY), 2022 Nov 9. PMID 36367773, Free PMC Article
  4. Inositol 1,4,5-trisphosphate signalling regulates the avoidance response to nose touch in Caenorhabditis elegans. Walker DS, et al. PLoS Genet, 2009 Sep. PMID 19730689, Free PMC Article
  5. Neuronal and intestinal protein kinase d isoforms mediate Na+ (salt taste)-induced learning. Fu Y, et al. Sci Signal, 2009 Aug 11. PMID 19671928

See all (80) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled dopamine receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemotaxis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of acetylcholine secretion, neurotransmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of axon regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to synapse IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of locomotion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of nematode pharyngeal pumping IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of nematode pharyngeal pumping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in thermotaxis IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8;Phosphoinositide phospholipase C
NP_001021346.1
  • Confirmed by transcript evidence
NP_001021347.1
  • Confirmed by transcript evidence
NP_001021348.1
  • Confirmed by transcript evidence
NP_001300014.1
  • Confirmed by transcript evidence
NP_001300016.1
  • Confirmed by transcript evidence
NP_001300018.1
  • Confirmed by transcript evidence
NP_001300020.1
  • Confirmed by transcript evidence
NP_001300022.1
  • Confirmed by transcript evidence
NP_001300024.1
  • Confirmed by transcript evidence
NP_001300026.1
  • Confirmed by transcript evidence
NP_001300028.1
  • Confirmed by transcript evidence
NP_001300030.1
  • Confirmed by transcript evidence
NP_001300032.1
  • Confirmed by transcript evidence
NP_001300034.1
  • Confirmed by transcript evidence
NP_001368552.1
  • Confirmed by transcript evidence
NP_001368553.1
  • Confirmed by transcript evidence
NP_001368554.1
  • Confirmed by transcript evidence
NP_001368555.1
  • Confirmed by transcript evidence
NP_001368556.1
  • Confirmed by transcript evidence
NP_001368557.1
  • Confirmed by transcript evidence
NP_001368558.1
  • Confirmed by transcript evidence
NP_001368559.1
  • Confirmed by transcript evidence
NP_001368560.1
  • Confirmed by transcript evidence
NP_001380184.1
  • Confirmed by transcript evidence
NP_001380185.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    20818..43704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001313089.4 → NP_001300018.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AV83
    Conserved Domains (7) summary
    cd00275
    Location:789 → 909
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:339 → 755
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:218 → 888
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:17 → 142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:1015 → 1057
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:1183 → 1324
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:249 → 335
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  2. NM_001380577.1 → NP_001368553.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ARQ7
    Conserved Domains (7) summary
    cd00275
    Location:870 → 990
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:339 → 495
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16200
    Location:147 → 327
    EFh_PI-PLCbeta; EF-hand motif found in metazoan phosphoinositide-specific phospholipase C (PI-PLC)-beta isozymes
    pfam06631
    Location:1096 → 1139
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:1252 → 1393
    PLC-beta_C; PLC-beta C terminal
    cl14615
    Location:733 → 836
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  3. NM_001392458.1 → NP_001380184.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AXI3
    Conserved Domains (6) summary
    cd00275
    Location:789 → 909
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:339 → 755
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16200
    Location:147 → 327
    EFh_PI-PLCbeta; EF-hand motif found in metazoan phosphoinositide-specific phospholipase C (PI-PLC)-beta isozymes
    pfam06631
    Location:1015 → 1058
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:1171 → 1312
    PLC-beta_C; PLC-beta C terminal

  4. NM_001313091.3 → NP_001300020.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AS74
    Conserved Domains (7) summary
    cd00275
    Location:810 → 930
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:339 → 776
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:218 → 909
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:17 → 142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:1036 → 1078
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:1204 → 1345
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:249 → 339
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  5. NM_001380579.1 → NP_001368555.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AV92
    Conserved Domains (5) summary
    cd08591
    Location:339 → 695
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02228
    Location:205 → 840
    PLN02228; Phosphoinositide phospholipase C
    cd13361
    Location:17 → 142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:955 → 998
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:1111 → 1252
    PLC-beta_C; PLC-beta C terminal

  6. NM_001313093.3 → NP_001300022.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ARR2
    Conserved Domains (7) summary
    cd00275
    Location:729 → 849
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:339 → 695
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02228
    Location:205 → 840
    PLN02228; Phosphoinositide phospholipase C
    cd13361
    Location:17 → 142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:955 → 997
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:1123 → 1264
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:249 → 339
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  7. NM_001380581.2 → NP_001368557.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ARR7
    Conserved Domains (8) summary
    cd00275
    Location:867 → 987
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:311 → 467
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam05109
    Location:500 → 640
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd16200
    Location:147 → 299
    EFh_PI-PLCbeta; EF-hand motif found in metazoan phosphoinositide-specific phospholipase C (PI-PLC)-beta isozymes
    pfam06631
    Location:1093 → 1136
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:1249 → 1390
    PLC-beta_C; PLC-beta C terminal
    cl14615
    Location:730 → 833
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  8. NM_001026177.6 → NP_001021348.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021348.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EBH0
    Conserved Domains (3) summary
    cd08591
    Location:339 → 495
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam09279
    Location:249 → 335
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  9. NM_001380578.2 → NP_001368554.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUL7
    Conserved Domains (6) summary
    cd08591
    Location:339 → 776
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02222
    Location:237 → 911
    PLN02222; phosphoinositide phospholipase C 2
    cd13361
    Location:17 → 142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16200
    Location:147 → 327
    EFh_PI-PLCbeta; EF-hand motif found in metazoan phosphoinositide-specific phospholipase C (PI-PLC)-beta isozymes
    pfam06631
    Location:1036 → 1079
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:1192 → 1333
    PLC-beta_C; PLC-beta C terminal

  10. NM_001380580.2 → NP_001368556.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AS80
    Conserved Domains (8) summary
    cd00275
    Location:948 → 1068
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:311 → 467
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam05109
    Location:500 → 640
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd16200
    Location:147 → 299
    EFh_PI-PLCbeta; EF-hand motif found in metazoan phosphoinositide-specific phospholipase C (PI-PLC)-beta isozymes
    pfam06631
    Location:1174 → 1217
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:1327 → 1471
    PLC-beta_C; PLC-beta C terminal
    cl14615
    Location:811 → 914
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  11. NM_001026175.5 → NP_001021346.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021346.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EBH0
    Conserved Domains (8) summary
    cd00275
    Location:895 → 1015
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:339 → 495
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:218 → 994
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:17 → 142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:1121 → 1163
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:1277 → 1418
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:249 → 339
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl14615
    Location:758 → 861
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  12. NM_001026176.3 → NP_001021347.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021347.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EBH0, Q6EZG7, Q95X30, Q9U6B9
    Conserved Domains (8) summary
    cd00275
    Location:895 → 1015
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:339 → 495
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:218 → 994
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:17 → 142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:1121 → 1163
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:1289 → 1430
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:249 → 339
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl14615
    Location:758 → 861
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  13. NM_001313087.3 → NP_001300016.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUL3
    Conserved Domains (8) summary
    cd00275
    Location:870 → 990
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:339 → 495
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:218 → 969
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:17 → 142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:1096 → 1138
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:1264 → 1405
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:249 → 339
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl14615
    Location:733 → 836
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  14. NM_001313103.4 → NP_001300032.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3ARS4
    Conserved Domains (7) summary
    cd00275
    Location:782 → 902
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:311 → 748
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:206 → 881
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:17 → 142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:1008 → 1050
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:1176 → 1317
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:221 → 311
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  15. NM_001380582.2 → NP_001368558.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AXJ6
    Conserved Domains (7) summary
    cd00275
    Location:842 → 962
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:311 → 467
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16200
    Location:147 → 299
    EFh_PI-PLCbeta; EF-hand motif found in metazoan phosphoinositide-specific phospholipase C (PI-PLC)-beta isozymes
    pfam06631
    Location:1068 → 1111
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:1224 → 1365
    PLC-beta_C; PLC-beta C terminal
    cl14615
    Location:705 → 808
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  16. NM_001380583.1 → NP_001368559.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUN1
    Conserved Domains (6) summary
    cd00275
    Location:761 → 881
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:311 → 727
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16200
    Location:147 → 299
    EFh_PI-PLCbeta; EF-hand motif found in metazoan phosphoinositide-specific phospholipase C (PI-PLC)-beta isozymes
    pfam06631
    Location:987 → 1030
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:1143 → 1284
    PLC-beta_C; PLC-beta C terminal

  17. NM_001313095.4 → NP_001300024.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AXJ0
    Conserved Domains (7) summary
    cd00275
    Location:948 → 1068
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:311 → 467
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:1174 → 1216
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:1342 → 1483
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:221 → 307
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl14615
    Location:811 → 914
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  18. NM_001313085.3 → NP_001300014.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AXH8
    Conserved Domains (7) summary
    cd00275
    Location:976 → 1096
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:339 → 495
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:1202 → 1244
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:1370 → 1511
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:249 → 339
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl14615
    Location:839 → 942
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  19. NM_001380576.2 → NP_001368552.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AS71
    Conserved Domains (8) summary
    cd00275
    Location:976 → 1096
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:339 → 495
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam05109
    Location:528 → 668
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd16200
    Location:147 → 327
    EFh_PI-PLCbeta; EF-hand motif found in metazoan phosphoinositide-specific phospholipase C (PI-PLC)-beta isozymes
    pfam06631
    Location:1202 → 1245
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:1355 → 1499
    PLC-beta_C; PLC-beta C terminal
    cl14615
    Location:839 → 942
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  20. NM_001313097.3 → NP_001300026.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUM3
    Conserved Domains (8) summary
    cd00275
    Location:867 → 987
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:311 → 467
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:206 → 966
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:17 → 142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:1093 → 1135
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:1261 → 1402
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:221 → 307
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl14615
    Location:730 → 833
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  21. NM_001313099.3 → NP_001300028.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AV97
    Conserved Domains (8) summary
    cd00275
    Location:842 → 962
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:311 → 467
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:206 → 941
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:17 → 142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:1068 → 1110
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:1236 → 1377
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:221 → 307
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl14615
    Location:705 → 808
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  22. NM_001313101.3 → NP_001300030.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AS85
    Conserved Domains (7) summary
    cd00275
    Location:761 → 881
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:311 → 727
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02952
    Location:206 → 860
    PLN02952; phosphoinositide phospholipase C
    cd13361
    Location:17 → 142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:987 → 1029
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:1155 → 1296
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:221 → 311
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  23. NM_001380584.1 → NP_001368560.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AVA5
    Conserved Domains (6) summary
    cd08591
    Location:311 → 748
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02222
    Location:209 → 883
    PLN02222; phosphoinositide phospholipase C 2
    cd13361
    Location:17 → 142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16200
    Location:147 → 299
    EFh_PI-PLCbeta; EF-hand motif found in metazoan phosphoinositide-specific phospholipase C (PI-PLC)-beta isozymes
    pfam06631
    Location:1008 → 1051
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:1164 → 1305
    PLC-beta_C; PLC-beta C terminal

  24. NM_001313105.3 → NP_001300034.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AXK2
    Conserved Domains (7) summary
    cd00275
    Location:701 → 821
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:311 → 667
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02228
    Location:218 → 812
    PLN02228; Phosphoinositide phospholipase C
    cd13361
    Location:17 → 142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam06631
    Location:927 → 969
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:1095 → 1236
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:221 → 311
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  25. NM_001392459.1 → NP_001380185.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AS90
    Conserved Domains (6) summary
    cd00275
    Location:701 → 821
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:311 → 667
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:17 → 142
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16200
    Location:147 → 299
    EFh_PI-PLCbeta; EF-hand motif found in metazoan phosphoinositide-specific phospholipase C (PI-PLC)-beta isozymes
    pfam06631
    Location:927 → 970
    DUF1154; Protein of unknown function (DUF1154)
    pfam08703
    Location:1083 → 1224
    PLC-beta_C; PLC-beta C terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EBH0.1

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