cul-3 Cullin family profile domain-containing protein;Cullin protein neddylation domain-containing protein;Cullin-3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cul-3
Official Full Name: Cullin family profile domain-containing protein;Cullin protein neddylation domain-containing protein;Cullin-3
Primary source: WormBase:WBGene00000838
Locus tag: CELE_Y108G3AL.1
See related: AllianceGenome:WB:WBGene00000838
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables POZ domain binding activity. Involved in several processes, including programmed cell death involved in cell development; protein polyubiquitination; and striated muscle myosin thick filament assembly. Part of Cul3-RING ubiquitin ligase complex. Is expressed in several structures, including anal depressor muscle; intestine; pharynx; reproductive system; and tail. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human CUL3 (cullin 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cul-3 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 6

Sequence:: Chromosome: V; NC_003283.11 (177579..185100)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KEL-8 is a substrate receptor for Cullin 3 ubiquitin ligases that is required for the proteolysis of GLR-1 receptors and suggest a novel postmitotic role in neurons for Kelch/CUL3 ubiquitin ligases.
Title: KEL-8 is a substrate receptor for CUL3-dependent ubiquitin ligase that regulates synaptic glutamate receptor turnover.
cullin (CUL)-3 as a component of E3 ligase and KEL-8 as the substrate adaptor of RPY-1.
Title: Control of rapsyn stability by the CUL-3-containing E3 ligase complex.
FIGL-1 by the CUL-3MEL-26 E3 ligase spatially restricts FIGL-1 function to mitotic cells, where it is required for correct progression through mitosis.
Title: The AAA-ATPase FIGL-1 controls mitotic progression, and its levels are regulated by the CUL-3MEL-26 E3 ligase in the C. elegans germ line.
the identification of a large family of BTB-domain proteins as substrate-specific adaptors for C. elegans CUL-3
Title: BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.
The BTB-containing protein MEL-26 is a component required for degradation of MEI-1 in vivo; importantly, MEL-26 specifically interacts with CUL-3 and MEI-1 in vivo and in vitro, and displays properties of a substrate-specific adaptor
Title: The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables POZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in programmed cell death involved in cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in programmed cell death involved in cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in striated muscle myosin thick filament assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Cul3-RING ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Cullin family profile domain-containing protein;Cullin protein neddylation domain-containing protein;Cullin-3

NP_001300214.1

Confirmed by transcript evidence

NP_001300215.1

Confirmed by transcript evidence

NP_001300216.1

Confirmed by transcript evidence

NP_503151.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

177579..185100

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_070750.8 → NP_503151.1 Cullin-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_503151.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17391, Q95Y32

Conserved Domains (3) summary

smart00182
Location:427 → 567

CULLIN; Cullin

pfam00888
Location:32 → 674

Cullin; Cullin family

pfam10557
Location:709 → 769

Cullin_Nedd8; Cullin protein neddylation domain
NM_001313285.3 → NP_001300214.1 Cullin family profile domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AY70

Conserved Domains (2) summary

pfam00888
Location:1 → 615

Cullin; Cullin family

pfam10557
Location:649 → 707

Cullin_Nedd8; Cullin protein neddylation domain
NM_001313286.3 → NP_001300215.1 Cullin family profile domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3ASX8

Conserved Domains (1) summary

COG5647
Location:1 → 240

COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
NM_001313287.2 → NP_001300216.1 Cullin protein neddylation domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AV81

Conserved Domains (1) summary

COG5647
Location:3 → 113

COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]