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abt-4 ABC transporter domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 178559, updated on 2-Nov-2024

Summary

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Official Symbol
abt-4
Official Full Name
ABC transporter domain-containing protein
Primary source
WormBase:WBGene00000022
Locus tag
CELE_Y39D8C.1
See related
AllianceGenome:WB:WBGene00000022
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including head; intestine; pharyngeal-intestinal valve; pharynx; and rectal gland cell. Human ortholog(s) of this gene implicated in pulmonary alveolar proteinosis. Orthologous to human ABCA3 (ATP binding cassette subfamily A member 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See abt-4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
16
Sequence:
Chromosome: V; NC_003283.11 (323777..330725, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene PHD finger protein 10;PHD-type domain-containing protein Neighboring gene Nuclear Hormone Receptor family Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DM domain-containing protein Neighboring gene PAZ domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CemOrange2 fusions facilitate multifluorophore subcellular imaging in C. elegans. Thomas BJ, et al. PLoS One, 2019. PMID 30913273, Free PMC Article
  2. Use of RNAi as a preliminary tool for screening putative receptors of nematicidal toxins from Bacillus thuringiensis. García-Montelongo M, et al. Arch Microbiol, 2021 May. PMID 33432376
  3. The ABC transporter gene family of Caenorhabditis elegans has implications for the evolutionary dynamics of multidrug resistance in eukaryotes. Sheps JA, et al. Genome Biol, 2004. PMID 15003118, Free PMC Article
  4. High-throughput in vivo analysis of gene expression in Caenorhabditis elegans. Hunt-Newbury R, et al. PLoS Biol, 2007 Sep. PMID 17850180, Free PMC Article
  5. ATP-binding cassette transporters are required for efficient RNA interference in Caenorhabditis elegans. Sundaram P, et al. Mol Biol Cell, 2006 Aug. PMID 16723499, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in lipid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ABC transporter domain-containing protein
NP_503175.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    323777..330725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070774.5 → NP_503175.1  ABC transporter domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503175.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9TXV8
    Conserved Domains (5) summary
    TIGR01188
    Location:1457 → 1755
    drrA; daunorubicin resistance ABC transporter ATP-binding subunit
    cd03263
    Location:586 → 815
    ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A
    COG1131
    Location:581 → 905
    CcmA; ABC-type multidrug transport system, ATPase component [Defense mechanisms]
    COG1277
    Location:377 → 524
    NosY; ABC-type transport system involved in multi-copper enzyme maturation, permease component [Posttranslational modification, protein turnover, chaperones]
    pfam12698
    Location:281 → 523
    ABC2_membrane_3; ABC-2 family transporter protein
Nucleotide Protein
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