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wago-10 PAZ domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 178560, updated on 2-Nov-2024

Summary

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Official Symbol
wago-10
Official Full Name
PAZ domain-containing protein
Primary source
WormBase:WBGene00020707
Locus tag
CELE_T22H9.3
See related
AllianceGenome:WB:WBGene00020707
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA endonuclease activity; miRNA binding activity; and single-stranded RNA binding activity. Predicted to be involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Is expressed in male. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See wago-10 in Genome Data Viewer
Location:
chromosome: V
Exon count:
7
Sequence:
Chromosome: V; NC_003283.11 (343428..347640)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ABC transporter domain-containing protein Neighboring gene ncRNA Neighboring gene DM domain-containing protein Neighboring gene Autophagy-related protein 9 Neighboring gene rRNA biogenesis protein RRP36

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility. Charlesworth AG, et al. Nucleic Acids Res, 2021 Sep 7. PMID 34329465, Free PMC Article
  2. Characterization of the distribution and dynamics of chromatin states in the C. elegans germline reveals substantial H3K4me3 remodeling during oogenesis. Mazzetto M, et al. Genome Res, 2024 Feb 7. PMID 38164610, Free PMC Article
  3. A comprehensive survey of C. elegans argonaute proteins reveals organism-wide gene regulatory networks and functions. Seroussi U, et al. Elife, 2023 Feb 15. PMID 36790166, Free PMC Article
  4. From early lessons to new frontiers: the worm as a treasure trove of small RNA biology. Youngman EM, et al. Front Genet, 2014. PMID 25505902, Free PMC Article
  5. Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi. Yigit E, et al. Cell, 2006 Nov 17. PMID 17110334

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables miRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RISC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasmic ribonucleoprotein granule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
PAZ domain-containing protein
NP_503177.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    343428..347640
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070776.5 → NP_503177.1  PAZ domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503177.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9TXN7
    Conserved Domains (3) summary
    cd02826
    Location:499 → 932
    Piwi-like; Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The ...
    cd02846
    Location:347 → 439
    PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
    pfam16488
    Location:478 → 515
    ArgoL2; Argonaute linker 2 domain
Nucleotide Protein
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