U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

cpr-8 Peptidase C1A papain C-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 178613, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
cpr-8
Official Full Name
Peptidase C1A papain C-terminal domain-containing protein
Primary source
WormBase:WBGene00021070
Locus tag
CELE_W07B8.1
See related
AllianceGenome:WB:WBGene00021070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be active in extracellular space and lysosome. Human ortholog(s) of this gene implicated in diabetes mellitus. Orthologous to human CTSB (cathepsin B). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See cpr-8 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (1134602..1139182)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Peptidase C1A papain C-terminal domain-containing protein Neighboring gene Cathepsin B-like cysteine proteinase 5 Neighboring gene ncRNA Neighboring gene ZP domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A nematode model to evaluate microdeletion phenotype expression. Antkowiak KR, et al. G3 (Bethesda), 2024 Feb 7. PMID 37956108, Free PMC Article
  2. Identifying evolutionarily conserved genes in the dietary restriction response using bioinformatics and subsequent testing in Caenorhabditis elegans. Ludewig AH, et al. Genes Nutr, 2014 Jan. PMID 24311442, Free PMC Article
  3. Autophagy Regulation Influences β-Amyloid Toxicity in Transgenic Caenorhabditis elegans. Lin H, et al. Front Aging Neurosci, 2022. PMID 35645788, Free PMC Article
  4. The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress. Li TY, et al. Nat Aging, 2021 Feb. PMID 33718883, Free PMC Article
  5. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Peptidase C1A papain C-terminal domain-containing protein
NP_503384.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    1134602..1139182
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070983.7 → NP_503384.1  Peptidase C1A papain C-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503384.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16289
    Conserved Domains (2) summary
    cd02620
    Location:79 → 330
    Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
    pfam08127
    Location:24 → 40
    Propeptide_C1; Peptidase family C1 propeptide

RNA

  1. NR_132498.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools