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madd-2 E3 ubiquitin-protein ligase TRIM9 [ Caenorhabditis elegans ]

Gene ID: 178619, updated on 2-Nov-2024

Summary

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Official Symbol
madd-2
Official Full Name
E3 ubiquitin-protein ligase TRIM9
Primary source
WormBase:WBGene00016539
Locus tag
CELE_C39F7.2
See related
AllianceGenome:WB:WBGene00016539
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein homodimerization activity; signaling receptor binding activity; and ubiquitin-protein transferase activity. Involved in several processes, including axon guidance; cell projection assembly; and protein ubiquitination. Located in several cellular components, including cell leading edge; neuronal cell body; and striated muscle dense body. Is expressed in several structures, including head mesodermal cell; neurons; ray precursor cell; reproductive system; and ventral uterine precursor. Used to study Opitz GBBB syndrome. Human ortholog(s) of this gene implicated in Opitz GBBB syndrome; anencephaly; and non-syndromic X-linked intellectual disability 101. Orthologous to several human genes including TRIM67 (tripartite motif containing 67) and TRIM9 (tripartite motif containing 9). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See madd-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
13
Sequence:
Chromosome: V; NC_003283.11 (1223897..1235455, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Fanconi-associated nuclease;HTH myb-type domain-containing protein;HTH_40 domain-containing protein Neighboring gene Plectrovirus-related protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene HET domain-containing protein;Transmembrane protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity. Wang Z, et al. J Cell Biol, 2014 Sep 1. PMID 25154398, Free PMC Article
  2. The Caenorhabditis elegans homolog of the Opitz syndrome gene, madd-2/Mid1, regulates anchor cell invasion during vulval development. Morf MK, et al. Dev Biol, 2013 Feb 1. PMID 23201576
  3. MADD-2, a homolog of the Opitz syndrome protein MID1, regulates guidance to the midline through UNC-40 in Caenorhabditis elegans. Alexander M, et al. Dev Cell, 2010 Jun 15. PMID 20627078
  4. LIN-12/Notch signaling instructs postsynaptic muscle arm development by regulating UNC-40/DCC and MADD-2 in Caenorhabditis elegans. Li P, et al. Elife, 2013 Mar 19. PMID 23539368, Free PMC Article
  5. The tripartite motif protein MADD-2 functions with the receptor UNC-40 (DCC) in Netrin-mediated axon attraction and branching. Hao JC, et al. Dev Cell, 2010 Jun 15. PMID 20627077, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Caenorhabditis elegans homolog of the Opitz syndrome gene, madd-2/Mid1, regulates anchor cell invasion during vulval development
    Title: The Caenorhabditis elegans homolog of the Opitz syndrome gene, madd-2/Mid1, regulates anchor cell invasion during vulval development.
  2. LIN-12/Notch signaling mediates type-2 vulval muscle cell development of muscle arms by regulating UNC-40 and MADD-2 activity.
    Title: LIN-12/Notch signaling instructs postsynaptic muscle arm development by regulating UNC-40/DCC and MADD-2 in Caenorhabditis elegans.
  3. an evolutionarily conserved function of TRIM-9 in the UNC-40/Frazzled-mediated UNC-6/Netrin attraction pathway
    Title: TRIM-9 functions in the UNC-6/UNC-40 pathway to regulate ventral guidance.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axon midline choice point recognition IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell projection assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal/ventral axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in striated muscle dense body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase TRIM9
NP_001122877.1
  • Confirmed by transcript evidence
NP_001300061.1
  • Confirmed by transcript evidence
NP_503395.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    1223897..1235455 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001129405.4 → NP_001122877.1  E3 ubiquitin-protein ligase TRIM9 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122877.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B1GRL4
    Conserved Domains (6) summary
    smart00502
    Location:320 → 445
    BBC; B-Box C-terminal domain
    cd00063
    Location:485 → 576
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd12889
    Location:573 → 749
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
    cd19764
    Location:275 → 313
    Bbox2_TRIM9-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM9, TRIM67 and similar proteins
    cd19803
    Location:207 → 253
    Bbox1_TRIM9-like_C-I; B-box-type 1 zinc finger found in tripartite motif-containing proteins, TRIM9, TRIM67 and similar proteins
    cl17238
    Location:2 → 31
    RING_Ubox; RING finger (Really Interesting New Gene) domain and U-box domain superfamily

  2. NM_070994.8 → NP_503395.1  E3 ubiquitin-protein ligase TRIM9 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503395.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9UAQ3
    Conserved Domains (5) summary
    smart00502
    Location:320 → 445
    BBC; B-Box C-terminal domain
    smart00184
    Location:7 → 33
    RING; Ring finger
    cd00063
    Location:499 → 590
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00643
    Location:271 → 313
    zf-B_box; B-box zinc finger
    cd12889
    Location:587 → 763
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67

  3. NM_001313132.3 → NP_001300061.1  E3 ubiquitin-protein ligase TRIM9 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AUR3
    Conserved Domains (1) summary
    cl02614
    Location:1 → 48
    SPRY; SPRY domain
Nucleotide Protein
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