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rab-1 RAB family [ Caenorhabditis elegans ]

Gene ID: 178620, updated on 2-Nov-2024

Summary

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Official Symbol
rab-1
Official Full Name
RAB family
Primary source
WormBase:WBGene00004266
Locus tag
CELE_C39F7.4
See related
AllianceGenome:WB:WBGene00004266
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activity. Predicted to be involved in autophagosome assembly and intracellular protein transport. Predicted to be active in endomembrane system. Is expressed in several structures, including hypodermis; intestinal muscle; nervous system; pharynx; and reproductive system. Orthologous to human RAB1A (RAB1A, member RAS oncogene family); RAB1B (RAB1B, member RAS oncogene family); and RAB1C (RAB1C, member RAS oncogene family (pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rab-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (1262629..1263989, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene HET domain-containing protein;Transmembrane protein Neighboring gene ncRNA Neighboring gene BACK domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Aurora kinase A-mediated phosphorylation triggers structural alteration of Rab1A to enhance ER complexity during mitosis. Zhang W, et al. Nat Struct Mol Biol, 2024 Feb. PMID 38177680
  2. Triggered Golgi membrane enrichment promotes PtdIns(4,5)P2 generation for plasma membrane repair. Meng X, et al. J Cell Biol, 2023 Aug 7. PMID 37158801, Free PMC Article
  3. The VAB-1 Eph receptor tyrosine kinase and SAX-3/Robo neuronal receptors function together during C. elegans embryonic morphogenesis. Ghenea S, et al. Development, 2005 Aug. PMID 16033794
  4. Dissecting worm immunity. Hodgkin J. Nat Immunol, 2004 May. PMID 15116111
  5. Direct interactions between C. elegans RAB-3 and Rim provide a mechanism to target vesicles to the presynaptic density. Gracheva EO, et al. Neurosci Lett, 2008 Oct 24. PMID 18721860, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RAB family
NP_503397.1
  • Product from WormBase gene class rab;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    1262629..1263989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_070996.7 → NP_503397.1  RAB family [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503397.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    I7FW32, Q9UAQ6
    Conserved Domains (2) summary
    smart00175
    Location:12 → 175
    RAB; Rab subfamily of small GTPases
    cd01869
    Location:10 → 175
    Rab1_Ypt1; Rab GTPase family 1 includes the yeast homolog Ypt1
Nucleotide Protein
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