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snt-5 C2 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 178631, updated on 2-Nov-2024

Summary

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Official Symbol
snt-5
Official Full Name
C2 domain-containing protein
Primary source
WormBase:WBGene00004925
Locus tag
CELE_R12A1.2
See related
AllianceGenome:WB:WBGene00004925
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable SNARE binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Predicted to be involved in calcium-dependent activation of synaptic vesicle fusion; regulation of calcium ion-dependent exocytosis; and vesicle fusion. Predicted to be located in membrane. Predicted to be active in several cellular components, including axon; exocytic vesicle; and synapse. Orthologous to several human genes including SYT10 (synaptotagmin 10); SYT3 (synaptotagmin 3); and SYT6 (synaptotagmin 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See snt-5 in Genome Data Viewer
Location:
chromosome: V
Exon count:
12
Sequence:
Chromosome: V; NC_003283.11 (1393112..1411559, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Rho-GAP domain-containing protein Neighboring gene DUF148 domain-containing protein Neighboring gene ncRNA Neighboring gene BPTI/Kunitz inhibitor domain-containing protein;Kunitz/Bovine pancreatic trypsin inhibitor domain protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
  2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion sensor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in calcium-dependent activation of synaptic vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
C2 domain-containing protein
NP_001300174.1
  • Confirmed by transcript evidence
NP_001300175.1
  • Confirmed by transcript evidence
NP_001300176.1
  • Confirmed by transcript evidence
NP_503409.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    1393112..1411559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_071008.5 → NP_503409.1  C2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503409.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16700
    Conserved Domains (2) summary
    cd00276
    Location:301 → 442
    C2B_Synaptotagmin; C2 domain second repeat present in Synaptotagmin
    cl14603
    Location:169 → 277
    C2; C2 domain

  2. NM_001313245.4 → NP_001300174.1  C2 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AY30
    Conserved Domains (2) summary
    cd00276
    Location:234 → 375
    C2B_Synaptotagmin; C2 domain second repeat present in Synaptotagmin
    cl14603
    Location:102 → 210
    C2; C2 domain

  3. NM_001313247.3 → NP_001300176.1  C2 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AV38
    Conserved Domains (2) summary
    cd00276
    Location:269 → 410
    C2B_Synaptotagmin; C2 domain second repeat present in Synaptotagmin
    cl14603
    Location:137 → 245
    C2; C2 domain

  4. NM_001313246.3 → NP_001300175.1  C2 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AST7
    Conserved Domains (2) summary
    cd00276
    Location:204 → 345
    C2B_Synaptotagmin; C2 domain second repeat present in Synaptotagmin
    cl14603
    Location:72 → 180
    C2; C2 domain
Nucleotide Protein
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