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tnt-4 Troponin T, skeletal muscle [ Caenorhabditis elegans ]

Gene ID: 178679, updated on 2-Nov-2024

Summary

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Official Symbol
tnt-4
Official Full Name
Troponin T, skeletal muscle
Primary source
WormBase:WBGene00006589
Locus tag
CELE_T08B1.2
See related
AllianceGenome:WB:WBGene00006589
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable tropomyosin binding activity. Involved in several processes, including nematode larval development; nematode pharyngeal gland morphogenesis; and nematode pharynx development. Predicted to be part of troponin complex. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple) and muscle tissue disease (multiple). Orthologous to human TNNT1 (troponin T1, slow skeletal type); TNNT2 (troponin T2, cardiac type); and TNNT3 (troponin T3, fast skeletal type). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tnt-4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (1989471..1992918, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Fungal lipase-like domain-containing protein Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene Aldehyde dehydrogenase Neighboring gene C-type lectin domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tissue expression of four troponin I genes and their molecular interactions with two troponin C isoforms in Caenorhabditis elegans. Ruksana R, et al. Genes Cells, 2005 Mar. PMID 15743415
  2. Integration of male mating and feeding behaviors in Caenorhabditis elegans. Gruninger TR, et al. J Neurosci, 2006 Jan 4. PMID 16399684, Free PMC Article
  3. Tissue-specific interactions of TNI isoforms with other TN subunits and tropomyosins in C. elegans: the role of the C- and N-terminal extensions. Amin MZ, et al. Biochim Biophys Acta, 2007 Apr. PMID 17369112
  4. Axin-Mediated Regulation of Lifespan and Muscle Health in C. elegans Requires AMPK-FOXO Signaling. Mallick A, et al. iScience, 2020 Dec 18. PMID 33319173, Free PMC Article
  5. Cell architecture: surrounding muscle cells shape gland cell morphology in the Caenorhabditis elegans pharynx. Raharjo WH, et al. Genetics, 2011 Nov. PMID 21868609, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. gene duplication led to evolution of troponin I
    Title: Tissue expression of four troponin I genes and their molecular interactions with two troponin C isoforms in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables tropomyosin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in muscle contraction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode pharyngeal gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode pharynx development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of muscle contraction IEA
Inferred from Electronic Annotation
more info
  
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of troponin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of troponin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Troponin T, skeletal muscle
NP_001263832.1
  • Confirmed by transcript evidence
NP_503544.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    1989471..1992918 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_071143.6 → NP_503544.2  Troponin T, skeletal muscle [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503544.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O44556

  2. NM_001276903.3 → NP_001263832.1  Troponin T, skeletal muscle [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263832.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    K8ERV5
Nucleotide Protein
Heading Accession and Version

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