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nuo-5 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 178735, updated on 2-Nov-2024

Summary

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Official Symbol
nuo-5
Official Full Name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Primary source
WormBase:WBGene00021562
Locus tag
CELE_Y45G12B.1
See related
AllianceGenome:WB:WBGene00021562
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 4 iron, 4 sulfur cluster binding activity and oxidoreductase activity, acting on NAD(P)H. Predicted to contribute to NADH dehydrogenase activity. Predicted to be involved in respiratory electron transport chain. Predicted to be part of respiratory chain complex I. Predicted to be active in membrane. Used to study mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in inherited metabolic disorder; mitochondrial complex I deficiency; and nuclear type mitochondrial complex I deficiency 5. Orthologous to human NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nuo-5 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (2698972..2706984)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene BACK domain-containing protein;BTB domain-containing protein;Kelch-like protein 8 Neighboring gene L-2-hydroxyglutarate dehydrogenase, mitochondrial Neighboring gene Zinc finger protein-like 1 homolog Neighboring gene VWFA domain-containing protein Neighboring gene ncRNA Neighboring gene G protein-coupled receptor;Serpentine Receptor, class T

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic modulators associated with regulatory surveillance of mitochondrial quality control, play a key role in regulating stress pathways and longevity in C. elegans. Sarkar A, et al. Life Sci, 2022 Feb 1. PMID 34953889
  2. Phloretin prolongs lifespan of Caenorhabditis elegans via inhibition of NDUFS1 and NDUFS6 at mitochondrial complex Ⅰ. Zhang Y, et al. Free Radic Biol Med, 2024 Aug 20. PMID 38705496
  3. Subcomplex Ilambda specifically controls integrated mitochondrial functions in Caenorhabditis elegans. Falk MJ, et al. PLoS One, 2009 Aug 12. PMID 19672299, Free PMC Article
  4. Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans. Maglioni S, et al. Nat Commun, 2022 May 12. PMID 35551180, Free PMC Article
  5. Proteasome activity contributes to pro-survival response upon mild mitochondrial stress in Caenorhabditis elegans. Sladowska M, et al. PLoS Biol, 2021 Jul. PMID 34252079, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to NADH dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on NAD(P)H IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone IC
Inferred by Curator
more info
  
involved_in respiratory electron transport chain IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex I ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
NP_503733.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    2698972..2706984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_071332.7 → NP_503733.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503733.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N4Y8
    Conserved Domains (5) summary
    PRK09130
    Location:32 → 717
    PRK09130; NADH dehydrogenase subunit G; Validated
    cd02773
    Location:252 → 630
    MopB_Res-Cmplx1_Nad11; MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase ...
    pfam09326
    Location:672 → 707
    NADH_dhqG_C; NADH-ubiquinone oxidoreductase subunit G, C-terminal
    pfam10588
    Location:113 → 152
    NADH-G_4Fe-4S_3; NADH-ubiquinone oxidoreductase-G iron-sulfur binding region
    pfam13510
    Location:30 → 106
    Fer2_4; 2Fe-2S iron-sulfur cluster binding domain
Nucleotide Protein
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