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ketn-1 Kettin homolog [ Caenorhabditis elegans ]

Gene ID: 178740, updated on 2-Nov-2024

Summary

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Official Symbol
ketn-1
Official Full Name
Kettin homolog
Primary source
WormBase:WBGene00004130
Locus tag
CELE_F54E2.3
See related
AllianceGenome:WB:WBGene00004130
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable actin binding activity. Located in I band. Is expressed in body wall musculature; muscle cell; pharynx; and reproductive system. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ketn-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
29
Sequence:
Chromosome: V; NC_003283.11 (2781939..2807860, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class J Neighboring gene pseudo Neighboring gene Lipoprotein Neighboring gene ncRNA Neighboring gene WAP domain-containing protein Neighboring gene ncRNA Neighboring gene CUB_2 domain-containing protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kettin, the large actin-binding protein with multiple immunoglobulin domains, is essential for sarcomeric actin assembly and larval development in Caenorhabditis elegans. Ono K, et al. FEBS J, 2020 Feb. PMID 31411810, Free PMC Article
  2. Molecular and biochemical characterization of kettin in Caenorhabditis elegans. Ono S, et al. J Muscle Res Cell Motil, 2005. PMID 16453162
  3. Sequence and expression of the kettin gene in Drosophila melanogaster and Caenorhabditis elegans. Kolmerer B, et al. J Mol Biol, 2000 Feb 18. PMID 10669599
  4. Caenorhabditis elegans kettin, a large immunoglobulin-like repeat protein, binds to filamentous actin and provides mechanical stability to the contractile apparatuses in body wall muscle. Ono K, et al. Mol Biol Cell, 2006 Jun. PMID 16597697, Free PMC Article
  5. The ALP-Enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegans. Han HF, et al. Mol Biol Cell, 2009 May. PMID 19261811, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kettin, the large actin-binding protein with multiple immunoglobulin domains, is essential for sarcomeric actin assembly and larval development in Caenorhabditis elegans.
    Title: Kettin, the large actin-binding protein with multiple immunoglobulin domains, is essential for sarcomeric actin assembly and larval development in Caenorhabditis elegans.
  2. Kettin is an important regulator of myofibrillar organization and provides mechanical stability to the myofibrils during contraction.
    Title: Caenorhabditis elegans kettin, a large immunoglobulin-like repeat protein, binds to filamentous actin and provides mechanical stability to the contractile apparatuses in body wall muscle.
  3. In Caenorhabditis elegans, the kettin gene is independent of the genes for other connectin/titin-related proteins. Immunofluorescent localization of kettin shows that it localizes to the I-bands in the obliquely striated body wall muscle.
    Title: Molecular and biochemical characterization of kettin in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in I band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in sarcomere IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Kettin homolog
NP_001294666.1
  • Confirmed by transcript evidence
NP_001294667.1
  • Confirmed by transcript evidence
NP_001294668.1
  • Confirmed by transcript evidence
NP_001294669.1
  • Confirmed by transcript evidence
NP_001303736.1
  • Confirmed by transcript evidence
NP_001303737.1
  • Confirmed by transcript evidence
NP_001364781.1
  • Confirmed by transcript evidence
NP_001364782.1
  • Confirmed by transcript evidence
NP_001364783.1
  • Confirmed by transcript evidence
NP_001364827.1
  • Confirmed by transcript evidence
NP_001364828.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    2781939..2807860 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001307737.5 → NP_001294666.1  Kettin homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294666.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLU0
    Conserved Domains (7) summary
    cd00096
    Location:3602 → 3673
    Ig; Immunoglobulin domain
    smart00408
    Location:2140 → 2208
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:3327 → 3406
    IG; Immunoglobulin
    smart00410
    Location:2799 → 2878
    IG_like; Immunoglobulin like
    pfam07679
    Location:4571 → 4660
    I-set; Immunoglobulin I-set domain
    pfam06582
    Location:2357 → 2382
    DUF1136; Repeat of unknown function (DUF1136)
    cl11960
    Location:4801 → 4886
    Ig; Immunoglobulin domain

  2. NM_001377593.1 → NP_001364783.1  Kettin homolog [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    pfam06582
    Location:1718 → 1743
    DUF1136; Repeat of unknown function (DUF1136)
    pfam07679
    Location:3932 → 4021
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:551 → 642
    Ig; Immunoglobulin domain

  3. NM_001377592.1 → NP_001364782.1  Kettin homolog [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    pfam07679
    Location:3932 → 4021
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:3949 → 3953
    Ig; Ig strand B [structural motif]
    cl11960
    Location:551 → 642
    Ig; Immunoglobulin domain

  4. NM_001307738.4 → NP_001294667.1  Kettin homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294667.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CLT3
    Conserved Domains (3) summary
    pfam07679
    Location:4530 → 4619
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:4547 → 4551
    Ig; Ig strand B [structural motif]
    cl11960
    Location:1190 → 1281
    Ig; Immunoglobulin domain

  5. NM_001307740.4 → NP_001294669.1  Kettin homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294669.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    V6CJB8
    Conserved Domains (3) summary
    pfam07679
    Location:4604 → 4693
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:4621 → 4625
    Ig; Ig strand B [structural motif]
    cl11960
    Location:1190 → 1281
    Ig; Immunoglobulin domain

  6. NM_001307739.4 → NP_001294668.1  Kettin homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294668.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0M7RDU5, A0A0M9JJ85, H2L074, H2L075, H2L076, Q5PY59, Q8MXD8, Q9NL87, V6CJB8, V6CKH1, V6CLP5, V6CLT3, V6CLU0, V6CLU5
    Conserved Domains (3) summary
    pfam07679
    Location:4645 → 4734
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:4662 → 4666
    Ig; Ig strand B [structural motif]
    cl11960
    Location:1190 → 1281
    Ig; Immunoglobulin domain

  7. NM_001377590.2 → NP_001364781.1  Kettin homolog [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    pfam07679
    Location:3891 → 3980
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:3908 → 3912
    Ig; Ig strand B [structural motif]
    cl11960
    Location:551 → 642
    Ig; Immunoglobulin domain

  8. NM_001377591.2 → NP_001364828.1  Kettin homolog [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    pfam07679
    Location:3965 → 4054
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:3982 → 3986
    Ig; Ig strand B [structural motif]
    cl11960
    Location:551 → 642
    Ig; Immunoglobulin domain

  9. NM_001377594.2 → NP_001364827.1  Kettin homolog [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    pfam07679
    Location:4006 → 4095
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:4023 → 4027
    Ig; Ig strand B [structural motif]
    cl11960
    Location:551 → 642
    Ig; Immunoglobulin domain

  10. NM_001316807.3 → NP_001303736.1  Kettin homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0M7RDU5
    Conserved Domains (6) summary
    cd00096
    Location:2110 → 2181
    Ig; Immunoglobulin domain
    smart00408
    Location:648 → 716
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:1307 → 1386
    IG_like; Immunoglobulin like
    pfam07679
    Location:3079 → 3168
    I-set; Immunoglobulin I-set domain
    pfam06582
    Location:865 → 890
    DUF1136; Repeat of unknown function (DUF1136)
    cl11960
    Location:3309 → 3394
    Ig; Immunoglobulin domain

  11. NM_001316808.3 → NP_001303737.1  Kettin homolog [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0M9JJ85
    Conserved Domains (6) summary
    cd00096
    Location:1973 → 2044
    Ig; Immunoglobulin domain
    smart00408
    Location:511 → 579
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:1170 → 1249
    IG_like; Immunoglobulin like
    pfam07679
    Location:2942 → 3031
    I-set; Immunoglobulin I-set domain
    pfam06582
    Location:728 → 753
    DUF1136; Repeat of unknown function (DUF1136)
    cl11960
    Location:3172 → 3257
    Ig; Immunoglobulin domain
Nucleotide Protein
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