mtm-9 Myotubularin-related protein 9 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mtm-9
Official Full Name: Myotubularin-related protein 9
Primary source: WormBase:WBGene00003479
Locus tag: CELE_Y39H10A.3
See related: AllianceGenome:WB:WBGene00003479
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables phosphatase binding activity. Involved in pinocytosis and regulation of cell migration. Located in cytosol and plasma membrane. Is expressed in several structures, including coelomocyte; epithelial cell; intestine; neurons; and vulva. Used to study centronuclear myopathy. Orthologous to human MTMR9 (myotubularin related protein 9). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mtm-9 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 5

Sequence:: Chromosome: V; NC_003283.11 (3743576..3749403)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

demonstrated that MTM-6 and MTM-9 function as part of a complex to regulate an endocytic pathway that involves the Arf6 GTPase; defined protein domains required for MTM-6 activity.
Title: Disease-related myotubularins function in endocytic traffic in Caenorhabditis elegans.
The authors conclude that regulation of endosomal trafficking by the MTM-6/MTM-9 myotubularin complex is required for the retromer-dependent recycling of MIG-14/Wls and Wnt secretion.
Title: Wnt signalling requires MTM-6 and MTM-9 myotubularin lipid-phosphatase function in Wnt-producing cells.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y39H10A_225.e (e-PCR)
- UniSTS:324313

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
NOT enables phosphatidylinositol-3-phosphate phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in pinocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Myotubularin-related protein 9

NP_504038.1

Confirmed by transcript evidence

NP_872167.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

3743576..3749403

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_182367.6 → NP_872167.2 Myotubularin-related protein 9 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_872167.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q965W9

Conserved Domains (2) summary

pfam06602
Location:72 → 411

Myotub-related; Myotubularin-like phosphatase domain

cl17171
Location:1 → 64

PH-like; Pleckstrin homology-like domain
NM_071637.7 → NP_504038.1 Myotubularin-related protein 9 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_504038.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q6F3C7, Q965W9

Conserved Domains (2) summary

cd13211
Location:1 → 108

PH-GRAM_MTMR9; Myotubularian (MTM) related 9 protein (MTMR9) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

pfam06602
Location:120 → 459

Myotub-related; Myotubularin-like phosphatase domain