rft-2 Riboflavin transporter;Riboflavin transporter rft-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rft-2
Official Full Name: Riboflavin transporter;Riboflavin transporter rft-2
Primary source: WormBase:WBGene00021626
Locus tag: CELE_Y47D7A.14
See related: AllianceGenome:WB:WBGene00021626
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables riboflavin transmembrane transporter activity. Involved in IRE1-mediated unfolded protein response. Predicted to be active in plasma membrane. Is expressed in intestine. Human ortholog(s) of this gene implicated in Brown-Vialetto-Van Laere syndrome 1; Brown-Vialetto-Van Laere syndrome 2; Fazio-Londe disease; and riboflavin deficiency. Orthologous to human SLC52A1 (solute carrier family 52 member 1); SLC52A2 (solute carrier family 52 member 2); and SLC52A3 (solute carrier family 52 member 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rft-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 7

Sequence:: Chromosome: V; NC_003283.11 (4443303..4450563, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Caenorhabditis elegans riboflavin transporters rft-2 (Y47D7A.14) expression is localized mainly to the intestine and pharynx.
Title: Identification and functional characterization of the Caenorhabditis elegans riboflavin transporters rft-1 and rft-2.

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General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables riboflavin transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables riboflavin transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables riboflavin transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in IRE1-mediated unfolded protein response	HEP more info	PubMed
involved_in riboflavin transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in riboflavin transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Riboflavin transporter;Riboflavin transporter rft-2

NP_001256040.1

Confirmed by transcript evidence

NP_001256041.1

Partially confirmed by transcript evidence

NP_001317793.1

Confirmed by transcript evidence

NP_001317853.1

Confirmed by transcript evidence

NP_001317854.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

4443303..4450563 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001269112.3 → NP_001256041.1 Riboflavin transporter rft-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256041.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A168H3J9, G4SDH4, G4SM24, Q95XZ2

Conserved Domains (1) summary

pfam06237
Location:306 → 402

DUF1011; Protein of unknown function (DUF1011)
NM_001269111.3 → NP_001256040.1 Riboflavin transporter rft-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256040.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G4SDH4

Conserved Domains (1) summary

pfam06237
Location:294 → 389

DUF1011; Protein of unknown function (DUF1011)
NM_001330869.3 → NP_001317793.1 Riboflavin transporter rft-2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

G4SDH4
NM_001330870.3 → NP_001317853.1 Riboflavin transporter [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A168HBC9
NM_001330871.3 → NP_001317854.1 Riboflavin transporter [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A168HBE9