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nas-9 Zinc metalloproteinase nas-9 [ Caenorhabditis elegans ]

Gene ID: 178875, updated on 2-Nov-2024

Summary

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Official Symbol
nas-9
Official Full Name
Zinc metalloproteinase nas-9
Primary source
WormBase:WBGene00003528
Locus tag
CELE_C37H5.9
See related
AllianceGenome:WB:WBGene00003528
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Is expressed in hypodermis; spermatheca; and uterus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nas-9 in Genome Data Viewer
Location:
chromosome: V
Exon count:
9
Sequence:
Chromosome: V; NC_003283.11 (4836027..4840013, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Nucleolar complex protein 3 homolog Neighboring gene Decapping nuclease Neighboring gene Secreted protein Neighboring gene Secreted protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Metalloproteases with EGF, CUB, and thrombospondin-1 domains function in molting of Caenorhabditis elegans. Suzuki M, et al. Biol Chem, 2004 Jun. PMID 15255192
  2. p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. Troemel ER, et al. PLoS Genet, 2006 Nov 10. PMID 17096597, Free PMC Article
  3. The astacin protein family in Caenorhabditis elegans. Möhrlen F, et al. Eur J Biochem, 2003 Dec. PMID 14653817
  4. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Zinc metalloproteinase nas-9
NP_001379790.1
  • Confirmed by transcript evidence
NP_741531.1
  • Partially confirmed by transcript evidence
NP_741532.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    4836027..4840013 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392505.1 → NP_001379790.1  Zinc metalloproteinase nas-9 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    smart00254
    Location:436 → 472
    ShKT; ShK toxin domain
    pfam01400
    Location:237 → 431
    Astacin; Astacin (Peptidase family M12A)

  2. NM_171927.3 → NP_741532.1  Zinc metalloproteinase nas-9 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741532.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P91137, Q8I7H6, Q95Q69
    Conserved Domains (3) summary
    smart00254
    Location:510 → 546
    ShKT; ShK toxin domain
    cd04280
    Location:316 → 505
    ZnMc_astacin_like; Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to ...
    pfam01400
    Location:311 → 505
    Astacin; Astacin (Peptidase family M12A)

  3. NM_171452.2 → NP_741531.1  Zinc metalloproteinase nas-9 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741531.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P91137
    Conserved Domains (3) summary
    smart00254
    Location:481 → 517
    ShKT; ShK toxin domain
    pfam01400
    Location:311 → 476
    Astacin; Astacin (Peptidase family M12A)
    cl00064
    Location:316 → 476
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P91137.2

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