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abhd-5.2 Abhydrolase domain-containing protein abhd-5.2 [ Caenorhabditis elegans ]

Gene ID: 178877, updated on 2-Nov-2024

Summary

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Official Symbol
abhd-5.2
Official Full Name
Abhydrolase domain-containing protein abhd-5.2
Primary source
WormBase:WBGene00016507
Locus tag
CELE_C37H5.3
See related
AllianceGenome:WB:WBGene00016507
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable carboxylic ester hydrolase activity and lysophosphatidic acid acyltransferase activity. Predicted to be involved in lipid homeostasis and phosphatidic acid biosynthetic process. Predicted to be active in lipid droplet and mitochondrion. Is expressed in hypodermis and intestine. Used to study Chanarin-Dorfman syndrome. Human ortholog(s) of this gene implicated in Chanarin-Dorfman syndrome; autosomal recessive congenital ichthyosis 1; and colon adenocarcinoma. Orthologous to human ABHD4 (abhydrolase domain containing 4, N-acyl phospholipase B) and ABHD5 (abhydrolase domain containing 5, lysophosphatidic acid acyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See abhd-5.2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (4844685..4847025)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene Coexpressed With Polycystins Neighboring gene Abhydrolase domain-containing protein abhd-5.1 Neighboring gene Annexin Neighboring gene Acetyltransferase;Acyl-coenzyme A thioesterase 8;RRM_2 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Correction: The Causative Gene in Chanarian Dorfman Syndrome Regulates Lipid Droplet Homeostasis in C. elegans. Xie M, et al. PLoS Genet, 2016 Dec. PMID 28002418, Free PMC Article
  2. The Causative Gene in Chanarian Dorfman Syndrome Regulates Lipid Droplet Homeostasis in C. elegans. Xie M, et al. PLoS Genet, 2015 Jun. PMID 26083785, Free PMC Article
  3. Neuronal lipolysis participates in PUFA-mediated neural function and neurodegeneration. Yang L, et al. EMBO Rep, 2020 Nov 5. PMID 33034119, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables lysophosphatidic acid acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Abhydrolase domain-containing protein abhd-5.2
NP_504297.1
  • Partially confirmed by transcript evidence
NP_872178.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    4844685..4847025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_071896.7 → NP_504297.1  Abhydrolase domain-containing protein abhd-5.2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504297.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H2KZ86, Q8I7H5
    Conserved Domains (1) summary
    cl26327
    Location:68 → 413
    Abhydrolase_1; alpha/beta hydrolase fold

  2. NM_182378.4 → NP_872178.1  Abhydrolase domain-containing protein abhd-5.2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_872178.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H2KZ86
    Conserved Domains (2) summary
    pfam00561
    Location:76 → 325
    Abhydrolase_1; alpha/beta hydrolase fold
    pfam12695
    Location:77 → 179
    Abhydrolase_5; Alpha/beta hydrolase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
H2KZ86.1

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