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mlk-1 Mitogen-activated protein kinase kinase kinase mlk-1 [ Caenorhabditis elegans ]

Gene ID: 178895, updated on 2-Nov-2024

Summary

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Official Symbol
mlk-1
Official Full Name
Mitogen-activated protein kinase kinase kinase mlk-1
Primary source
WormBase:WBGene00003374
Locus tag
CELE_K11D12.10
See related
AllianceGenome:WB:WBGene00003374
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein kinase C binding activity; receptor tyrosine kinase binding activity; and scaffold protein binding activity. Involved in several processes, including MAPK cascade; determination of adult lifespan; and positive regulation of axon extension involved in regeneration. Predicted to be active in cytoplasm. Is expressed in body wall musculature; hypodermis; intestine; neurons; and pharynx. Orthologous to several human genes including MAP3K21 (mitogen-activated protein kinase kinase kinase 21) and MAP3K9 (mitogen-activated protein kinase kinase kinase 9). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mlk-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
17
Sequence:
Chromosome: V; NC_003283.11 (5056378..5064811, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene C2H2-type domain-containing protein Neighboring gene Coexpressed With Polycystins Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Copper transport protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Recovery Associated with Dendrite Regeneration in PVD Neuron of Caenorhabditis elegans. Brar HK, et al. eNeuro, 2024 May. PMID 38548333, Free PMC Article
  2. Neuronal development in Caenorhabditis elegans is regulated by inhibition of an MLK MAP kinase pathway. Baker ST, et al. Genetics, 2015 Jan. PMID 25339611, Free PMC Article
  3. The growth factor SVH-1 regulates axon regeneration in C. elegans via the JNK MAPK cascade. Li C, et al. Nat Neurosci, 2012 Mar 4. PMID 22388962
  4. Caffeine-induced food-avoidance behavior is mediated by neuroendocrine signals in Caenorhabditis elegans. Min H, et al. BMB Rep, 2017 Jan. PMID 27697105, Free PMC Article
  5. The C. elegans Discoidin Domain Receptor DDR-2 Modulates the Met-like RTK-JNK Signaling Pathway in Axon Regeneration. Hisamoto N, et al. PLoS Genet, 2016 Dec. PMID 27984580, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase C binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables scaffold protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in JNK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon regeneration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of axon extension involved in regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of axon regeneration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of axon regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to copper ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to starvation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Mitogen-activated protein kinase kinase kinase mlk-1
NP_001300151.1
  • Confirmed by transcript evidence
NP_001300152.1
  • Confirmed by transcript evidence
NP_741536.1
  • Confirmed by transcript evidence
NP_741537.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    5056378..5064811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001313222.3 → NP_001300151.1  Mitogen-activated protein kinase kinase kinase mlk-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0K3AS83, A0A0K3AV08, H2KYR3, Q8T7Z0
    Conserved Domains (3) summary
    smart00221
    Location:153 → 450
    STYKc; Protein kinase; unclassified specificity
    cl17036
    Location:75 → 124
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:156 → 446
    PKc_like; Protein Kinases, catalytic domain

  2. NM_171928.7 → NP_741537.1  Mitogen-activated protein kinase kinase kinase mlk-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741537.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0K3AV08
    Conserved Domains (3) summary
    smart00221
    Location:153 → 450
    STYKc; Protein kinase; unclassified specificity
    cl17036
    Location:75 → 124
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:156 → 446
    PKc_like; Protein Kinases, catalytic domain

  3. NM_171456.8 → NP_741536.1  Mitogen-activated protein kinase kinase kinase mlk-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741536.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0K3AV08
    Conserved Domains (3) summary
    smart00221
    Location:153 → 450
    STYKc; Protein kinase; unclassified specificity
    cl17036
    Location:75 → 124
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:156 → 446
    PKc_like; Protein Kinases, catalytic domain

  4. NM_001313223.3 → NP_001300152.1  Mitogen-activated protein kinase kinase kinase mlk-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0K3AV08
    Conserved Domains (3) summary
    smart00221
    Location:153 → 450
    STYKc; Protein kinase; unclassified specificity
    cl17036
    Location:75 → 124
    SH3; Src Homology 3 domain superfamily
    cl21453
    Location:156 → 446
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0K3AV08.1

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