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syp-2 Biogenesis of lysosome-related organelles complex 1 subunit 1 [ Caenorhabditis elegans ]

Gene ID: 178938, updated on 2-Nov-2024

Summary

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Official Symbol
syp-2
Official Full Name
Biogenesis of lysosome-related organelles complex 1 subunit 1
Primary source
WormBase:WBGene00006376
Locus tag
CELE_C24G6.1
See related
AllianceGenome:WB:WBGene00006376
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in positive regulation of reciprocal meiotic recombination and synaptonemal complex assembly. Located in central element. Is expressed in germ cell; germ line; gonad; and midbody. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See syp-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (5536487..5537717)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene receptor protein-tyrosine kinase Neighboring gene Ground-like domain-containing protein Neighboring gene putative peptidyl-tRNA hydrolase 2 Neighboring gene Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial Neighboring gene Cystic Fibrosis Transmembrane conductance regulator homolog Neighboring gene Putative UDP-glucuronosyltransferase ugt-48 Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A motor independent requirement for dynein light chain in Caenorhabditis elegans meiotic synapsis. Fielder SM, et al. Genetics, 2022 Jan 4. PMID 34788833, Free PMC Article
  2. HTP-1-dependent constraints coordinate homolog pairing and synapsis and promote chiasma formation during C. elegans meiosis. Martinez-Perez E, et al. Genes Dev, 2005 Nov 15. PMID 16291646, Free PMC Article
  3. Crossing over is coupled to late meiotic prophase bivalent differentiation through asymmetric disassembly of the SC. Nabeshima K, et al. J Cell Biol, 2005 Feb 28. PMID 15738262, Free PMC Article
  4. The MAP kinase pathway coordinates crossover designation with disassembly of synaptonemal complex proteins during meiosis. Nadarajan S, et al. Elife, 2016 Feb 27. PMID 26920220, Free PMC Article
  5. Sexual dimorphic regulation of recombination by the synaptonemal complex in C. elegans. Cahoon CK, et al. Elife, 2023 Oct 5. PMID 37796106, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in meiotic chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reproductive process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptonemal complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in central element IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptonemal complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Biogenesis of lysosome-related organelles complex 1 subunit 1
NP_504462.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    5536487..5537717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072061.7 → NP_504462.1  Biogenesis of lysosome-related organelles complex 1 subunit 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504462.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76388
Nucleotide Protein
Heading Accession and Version

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