crn-2 Deoxyribonuclease TATDN1 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: crn-2
Official Full Name: Deoxyribonuclease TATDN1
Primary source: WormBase:WBGene00000795
Locus tag: CELE_CD4.2
See related: AllianceGenome:WB:WBGene00000795
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DNA nuclease activity. Involved in apoptotic DNA fragmentation and apoptotic cell clearance. Predicted to be active in cytosol. Is expressed in head; intestine; and tail. Orthologous to human TATDN1 (TatD DNase domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See crn-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 4

Sequence:: Chromosome: V; NC_003283.11 (5594615..5595842)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

CD4.4 (e-PCR)
- UniSTS:316456

CD4.3 (e-PCR)
- UniSTS:320700

CD4.2 (e-PCR)
- UniSTS:320490

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA nuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity, acting on ester bonds	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA 3'-5' DNA exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in apoptotic DNA fragmentation	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic DNA fragmentation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	HEP more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: Deoxyribonuclease TATDN1

NP_504476.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

5594615..5595842

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_072075.8 → NP_504476.1 Deoxyribonuclease TATDN1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_504476.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EG18

Conserved Domains (2) summary

cd01310
Location:6 → 284

TatD_DNAse; TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity.

pfam00702
Location:21 → 96

Hydrolase; haloacid dehalogenase-like hydrolase