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peli-1 Protein pellino [ Caenorhabditis elegans ]

Gene ID: 178959, updated on 2-Nov-2024

Summary

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Official Symbol
peli-1
Official Full Name
Protein pellino
Primary source
WormBase:WBGene00017766
Locus tag
CELE_F25B4.2
See related
AllianceGenome:WB:WBGene00017766
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination. Is expressed in several structures, including body wall musculature; intestine; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to several human genes including PELI2 (pellino E3 ubiquitin protein ligase family member 2) and PELI3 (pellino E3 ubiquitin protein ligase family member 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See peli-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (5709418..5712331)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene C-type lectin domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Aminomethyltransferase Neighboring gene Neuropeptide CCHamide-1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fine tuning of RFX/DAF-19-regulated target gene expression through binding to multiple sites in Caenorhabditis elegans. Chu JS, et al. Nucleic Acids Res, 2012 Jan. PMID 21908398, Free PMC Article
  2. Forkhead transcription factor FKH-8 cooperates with RFX in the direct regulation of sensory cilia in Caenorhabditis elegans. Brocal-Ruiz R, et al. Elife, 2023 Jul 14. PMID 37449480, Free PMC Article
  3. MEX-3 interacting proteins link cell polarity to asymmetric gene expression in Caenorhabditis elegans. Huang NN, et al. Development, 2002 Feb. PMID 11830574
  4. The C. elegans regulatory factor X (RFX) DAF-19M module: A shift from general ciliogenesis to cell-specific ciliary and behavioral specialization. Ahn S, et al. Cell Rep, 2022 Apr 12. PMID 35417689
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of Toll signaling pathway IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein pellino
NP_001370430.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    5709418..5712331
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383308.2 → NP_001370430.1  Protein pellino [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22967, Q9NAP3
    Conserved Domains (1) summary
    pfam04710
    Location:17 → 445
    Pellino
Nucleotide Protein
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